Disinhibition is a cardinal feature of the behavioural variant of frontotemporal dementia, presenting as impulsive and impetuous behaviours that are often difficult to manage. The options for symptomatic treatments are limited, but a potential target for therapy is the restoration of serotonergic function, which is both deficient in behavioural variant frontotemporal dementia and closely associ...

Prediction of human pharmacokinetics of new drugs, as well as other disposition attributes, has become a routine practice in drug research and development. Prior to the 1990s, drug disposition science was used in a mostly descriptive manner in the drug development phase. With the advent of in vitro methods and availability of human-derived reagents for in vitro studies, drugdisposition scientis...

Despite the national decline in the number of employed workers in 1975, the number of workers covered lnder most types of employee-benefit plans increased slightly. Contributions and benefit payments underwent the greatest change. Total contributions increased 17 percent and benefit payments rose 14 percent. In part this change can be attributed to inflation, but it also reflects real growth in...

Data was drawn primarily from the Pakistan Fertility Survey (PFS) conducted on a sample basis for the entire country in 1975 in an effort to investigate and identify any rural-urban differentials in fertility and to try to explain them in terms of socioeconomic and demographic factors. The Survey included a national random sample of 4949 ever-married women, aged 15-49 (1886 in urban areas and ...