نتایج جستجو برای: قاعده همدمای خطی lir
تعداد نتایج: 38846 فیلتر نتایج به سال:
The inhibitory leukocyte Ig-like receptor 1 (LIR-1, also known as ILT2, CD85j, or LILRB1) was identified by its high affinity for the human CMV (HCMV) MHC class I homolog gpUL18. The role of this LIR-1-gpUL18 interaction in modulating NK recognition during HCMV infection has previously not been clearly defined. In this study, LIR-1(+) NKL cell-mediated cytotoxicity was shown to be inhibited by ...
Leukocyte Ig-like receptor (LIR) 1 (CD85j/ILT2/LILRB1) is an inhibitory receptor with broad specificity for MHC class I (MHC-I) and the human CMV MHC-I homologue UL18. LIR-1 can inhibit NK cells through the conventional interaction with MHC-I expressed on a target cell (in trans) but the nature and the effects of LIR-1 interactions with MHC-I in cis are not well understood. Here we show that MH...
UL18 is a human cytomegalovirus class I MHC (MHCI) homolog that binds the host inhibitory receptor LIR-1 and the only known viral MHC homolog that presents peptides. The 2.2-A structure of a LIR-1/UL18/peptide complex reveals increased contacts and optimal surface complementarity in the LIR-1/UL18 interface compared with LIR/MHCI interfaces, resulting in a >1,000-fold higher affinity. Despite s...
Pembelajaran tari menggunakan tembang lagu Lir-ilir, ini memiliki banyak makna yang dapat diajarkan untuk anak usia dini. Penelitian merupakan penelitian bertujuan menggambarkan bagaimana isi konten Lir-ilir adalah pendekatan kualitatif deskriptif. Diawali dengan melakukan analisis data sekunder mengenai gambaran terkait kegiatan pembelajaran seni lir-ilir di Taman Kanak-kanak. Dari hasil Taria...
BACKGROUND The rise in LDL with egg feeding in lean insulin-sensitive (LIS) participants is 2- and 3-fold greater than in lean insulin-resistant (LIR) and obese insulin-resistant (OIR) participants, respectively. OBJECTIVE We determined whether differences in cholesterol absorption, synthesis, or both could be responsible for these differences by measuring plasma sterols as indexes of cholest...
Leukocyte Ig-like receptor (LIR)-1 is a member of the Ig superfamily which has been shown to bind the human cytomegalovirus MHC class I homologue UL-18 protein. In this study, we have analyzed the expression and function of LIR-1 in human NK cells. We show that LIR-1 is expressed by a subset of NK cells variable in size among different donors. When compared to the known HLA class I-specific NK ...
For the first time, we investigate the X-ray/infrared (IR) correlation for star-forming galaxies (SFGs) at z ∼ 1, using SPIRE submm data from the recently launched Herschel Space Observatory and deep X-ray data from the 2-Ms Chandra Deep Field-North survey. We examine the X-ray/IR correlation in the soft X-ray (SX; 0.5–2 keV) and hard X-ray (HX; 2–10 keV) bands by comparing our z ∼ 1 SPIRE-dete...
Likelihood-based Imprecise Regression (LIR) is a recently introduced approach to regression with imprecise data. Here we consider a robust regression method derived from the general LIR approach and we establish an exact algorithm to determine the set-valued result of the LIR analysis in the special case of simple linear regression with interval data.
The role of different receptors in natural-killer- (NK-) cell-mediated cytotoxicity against multiple myeloma (MM) cells is unknown. We investigated if an enhancement of NK-cell-mediated cytotoxicity against MM could be reached by blocking of the inhibitory leukocyte immunoglobulin-like receptor 1 (LIR-1). Our investigations revealed high levels of LIR-1 expression not only on the NK cell line N...
We investigated the distribution and projection patterns of central and peripheral glutamate-like immunoreactive (GLU-LIR) neurons in the adult and developing nervous system of Lymnaea. Altogether, 50-60 GLU-LIR neurons are present in the adult central nervous system. GLU-LIR labeling is shown in the interganglionic bundle system and at the varicosities in neuropil of the central ganglia. In th...
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