The novel immunosuppressive drug O-hydroxyethyl-D(Ser)8-cyclosporine (SDZ IMM 125) and cyclosporine A (CyA) were compared in different in vitro models with respect to hepatocellular side effects. SDZ IMM 125 was less lipophilic than CyA and also decreased liposomal membrane anisotropy less. Furthermore, SDZ IMM 125 increased Na+ and Ca++ permeability across the liposomal membranes significantly...

Recent trends in the design of educational interactive multimedia (IMM) have tended to move away from instructivist approaches and towards constructivist designs. Problem-based learning (PBL) is one of a number of constructivist approaches to educational design, best known for its use in medical education. Application of PBL as a design framework for design of educational IMM (IMM-PBL) has been...

Spermatogonial stem cell transplantation is a technique that has potential in livestock to enhance genetic gain and generate transgenic offspring through the male germ line. A means for depletion of endogenous germ cells in a recipient's seminiferous tubules is necessary for this technology to be applied. The objectives of this study were to evaluate several methods for depletion of endogenous ...

The unscented Kalman filter (UKF) is adopted in the interacting multiple model (IMM) framework to deal with the system nonlinearity in navigation applications. The adaptive tuning system (ATS) is employed for assisting the unscented Kalman filter in the IMM framework, resulting in an interacting multiple model adaptive unscented Kalman filter (IMM-AUKF). Two models, a standard UKF and an adapti...

PURPOSE The purpose of this study was to determine whether endurance and strength hand grip exercises during 3-week upper limb immobilization preserve muscle oxidative capacity, endurance performance and strength. METHODS Ten healthy adult men underwent non-dominant forearm immobilization by plaster cast for 21 days. Five healthy adult subjects were designated as the immobilization (IMM) grou...

Nonalcoholic fatty liver disease (NAFLD), the most common chronic liver disease in humans, is characterized by the accumulation of triacylglycerols (TGs) in hepatocytes. We tested whether 2',3',5'-tri-acetyl-N6-(3-hydroxylaniline) adenosine (IMM-H007) can eliminate hepatic steatosis in hamsters fed a high-fat diet (HFD), as a model of NAFLD. Compared with HFD-only controls, IMM-H007 treatment s...

The immunosuppressive cyclosporine A derivative, O-hydroxyethyl-D(Ser)(8)-cyclosporine (SDZ IMM 125), was examined for its ability to induce apoptosis in rat hepatocytes cultured for 4 or 20 h. Four hours after SDZ IMM 125 treatment, chromatin condensation and fragmentation, and the number of terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeled and Annexin V-positive cell...

OBJECTIVES The Sysmex XE-5000 instruments (Sysmex, Kobe, Japan) count immature granulocytes (IGs) and use the "Imm Gran?" flag to signal unreliable results. This study investigated the usefulness of the "Imm Gran?" flag and the analytical and diagnostic performance of the IG measurements in a side-by-side evaluation. METHODS In total, 408 samples were analyzed on three XE-5000 instruments. Th...

the objective of the present study was to compare the efficacy of conventional and extendedintramammary (imm) therapy of persistent subclinical mastitis in lactating dairy cattle using nafcillinpenicillin-dihydrostreptomycin combination (npd). sixty-five dairy cows with 126 infected quarters were enrolled in the study. infected cows were allocated randomly to 1 of 3 different treatment regimens...