BACKGROUND A new series of imidazothioxanthones has recently been synthesized as potential anticancer agents with the aim of overcoming drug resistance. The route of synthesis and DNA-binding properties of the compounds were reported previously. This paper describes the general structure-activity relationships for the class of imidazothioxanthones in panels of human and murine tumor cell lines ...

A new one-pot approach was developed to construct the 11H-indolo[3,2-c]quinoline scaffold through a gold-catalysed reaction of 2-[(2-aminophenyl)ethynyl]phenylamine derivatives with aldehydes. The broad scope and the high regioselectivity of this new protocol as well as the mild and neutral reaction conditions make it a viable alternative to the previously reported procedures.

Resistance exercise (RE) can lower blood glucose in people with type 2 diabetes (T2D). However, greater clarity is needed regarding the RE intensity and time required for this acute response. Therefore, aim of study was to compare responses on second day recovery from moderate vs. high-intensity women T2D. Twelve T2D (55.2 ± 4.0 years; 70.1 11.4 kg; 155.7 3.3 cm) performed two experimental sess...

To the Editor: Ashbeck et al. (1) report that components of metabolic syndrome (MS) that capture impaired glucose uptake increase the odds of colorectal metachronous neoplasia. I would like to add the following comments to strengthen some issues of this theme. (a) Insulin resistance in obesity, specifically within adipose tissue, is thought to be caused by increased glucocorticoids (2). Further...

’ INTRODUCTION Since the development of electrospray ionization for mass spectrometry (MS), several MS-based approaches have been developed for characterizing structures of gas-phase protein ions. These can be categorized as either chemical or physicalmethods. Chemical methods include: ion ion and ion molecule reactions, detection of noncovalent adducts, 9 and monitoring of hydrogen/deuterium (...

A metal-free, TBHP-promoted economical route is developed via the sp(2) C-H bond functionalization strategy for the synthesis of indenoquinolinones, 4-azafluorenones and fluorenones. Reactions provided excellent yield of the products under mild conditions. We have successfully synthesized 11H-indeno[1,2-b]quinolin-11-one, an antibacterial agent, in excellent yields.