parent ACsEx.A Concrete children ACsEx.B1, ACsEx.B2, ACsEx1.B3 Class ACsEx.B1: Inherited methods B1.a2(), B1.a3(), B1.a4(P), B1.a7() Class ACsEx.B2: Inherited methods B2.a1(P), B2.a4(P), B2.a6(), B2.a7(), B2.a8(int) Class ACsEx1.B3: Inherited methods B3.a4(P), B3.a6(), B3.a7(), B3.a8(int) for the classes ACsEx.A, ACsEx.B1, ACsEx.B2, and ACsEx1.B3 from the code in Figure 1, the data in Table IV ...

The four encapsidated RNAs of brome mosaic virus (BMV; B1, B2, B3, and B4) contain a highly conserved 3' 200-nucleotide (nt) region encompassing the tRNA-like structure (TLS) which is required for packaging in vitro (Y. G. Choi, T. W. Dreher, and A. L. N. Rao, Proc. Natl. Acad. Sci. USA 99:655-660, 2002). To validate these observations in vivo, we performed packaging assays using Agrobacterium-...

B3 is a tumor-reactive monoclonal antibody (mAb) that binds to a limited number of normal tissues. Immunotoxins made with B3 coupled to either Pseudomonas exotoxin (PE) or recombinant forms of PE with a deletion of the cell-binding domain (LysPE40) have been shown to cause complete tumor regression in nude mice bearing a rapidly growing A431 (L. H. Pai et al., Proc. Natl. Acad. Sci. USA, 88: 33...

b3-Adrenoceptor agonists have recently been introduced for the treatment of overactive urinary bladder syndrome. Their target, the b3-adrenoceptor, was discovered much later than b1and b2-adrenoceptors and exhibits unique properties which make extrapolation of findings from the other two subtypes difficult and the b3-adrenoceptor a less-understood subtype. This article discusses three aspects o...

Introduction Lessons captured from interviews with 12 European regions are represented in a new instrument, the B3-Maturity Model (B3-MM). B3-MM aims to assess maturity along 12 dimensions reflecting the various aspects that need to be managed in order to deliver integrated care. The objective of the study was to test the content validity of B3-MM as part of SCIROCCO (Scaling Integrated Care in...

Increasing evidence suggests that AR (androgen receptor) acetylation is critical for prostate cancer cell growth. In the present study, we identified Pro-B3 (procyanidin B3) as a specific HAT (histone acetyltransferase) inhibitor. Pro-B3 selectively inhibited the activity of HATs, but not other epigenetic enzymes. Pro-B3 substantially inhibited the p300-mediated AR acetylation, both in vitro an...

Integrins are transmembrane receptors composed ofa andb subunits that mediate bidirectional signaling between the extracellular matrix and the cell interior. Among the best studied integrins is aIIbb3, which is required for hemostasis and platelet involvement in thrombosis. The related b3 integrin, aVb3, is expressed at low levels in platelets and better expressed in several other hematopoietic...

Sustained infection of HeLa cells by Coxsackie B3 virus, dependent on presence of viral inhibitor in culture medium, was achieved. Persistent treatment of carrier cultures with anti-Coxsackie B3 hyperimmune monkey serum eventually eliminated virus from carrier cultures indicating that a lysogenic virus-cell relationship was not operative. Free virus was produced continuously by carrier cultures...