BACKGROUND TTN-encoded titin, CSRP3-encoded muscle LIM protein, and TCAP-encoded telethonin are Z-disc proteins essential for the structural organization of the cardiac sarcomere and the cardiomyocyte's stretch sensor. All three genes have been established as cardiomyopathy-associated genes for both dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM). Here, we sought to character...

The efficacy and safety of the long-term experience with targeted cryoablation of prostate cancer (TCAP) at a community hospital is retrospectively reviewed. A series of 590 consecutive patients who underwent TCAP as primary therapy with curative intent for localized or locally advanced prostate cancer from March 1993 to September 2001 were identified. Patients were stratified into 3 risk group...

Limb-girdle muscular dystrophy 2G is caused by mutations in the telethonin (TCAP) gene in chromosome 17q11-12. This rare form of hereditary muscle disease was originally described in Brazilian patients and was recently identified in Chinese and Moldavian patients. We present the first Portuguese patient with a limb-girdle muscular dystrophy caused by a mutation in the TCAP gene. A Caucasian mal...

the current study conducted a finite element (fe) and experimental investigation on tubular channel angular pressing as a noble severe plastic deformation technique for producing ultrafine grained and nanostructure tubular components. to examine the effects of the tcap process on the strain distribution and deformation behavior, fe simulations were employed. the fe results demonstrated that equ...

Tubular channel angular pressing (TCAP) is a recently invented novel severe plastic deformation technique for producing UFG tubes. Plastic deformation analysis using the finite element method (FEM) was carried out to investigate the effects of trapezoidal channel geometry on strain inhomogeneity index (SII), strain level and required load compared to previously used channel geometries. The resu...

Teneurins are transmembrane proteins consisting of four paralogues (Ten-1-4), notably expressed in the central nervous system during development. All teneurins contain a bioactive peptide in their carboxyl terminal named teneurin C-terminal associated peptide (TCAP). The present study analyzed the detailed distribution of teneurin-2-like immunoreactive (Ten-2-LI) cells in developing and mature ...

AlSi11 matrix composites reinforced with SiC particles have been fabricated by high pressure die casting assisted ultrasonic mixing. Severe plastic deformation process was performed on the as cast AlSi/2wt.%SiC composite using modified channel twisted output (TCAP) at three temperatures of 350, 400 and 450 °C. The TCAP tool consists helical part in horizontal area allowing for simulation back t...

The transverse (t)-tubule system plays an essential role in healthy and diseased heart muscle, particularly in Ca(2+)-induced Ca(2+) release (CICR), and its structural disruption is an early event in heart failure. Both mechanical overload and unloading alter t-tubule structure, but the mechanisms mediating the normally tight regulation of the t-tubules in response to load variation are poorly ...

Teneurins are multifunctional transmembrane proteins that are found in all multicellular animals and exist as four paralogous forms in vertebrates. They are highly expressed in the central nervous system, where they exert their effects, in part, by high-affinity binding to latrophilin (LPHN), a G-protein coupled receptor (GPCR) related to the adhesion and secretin GPCR families. The teneurin C-...