نتایج جستجو برای: فرآیند خودهمبسته 1ar
تعداد نتایج: 32208 فیلتر نتایج به سال:
1and 2-adrenergic receptors ( ARs) are known to differentially regulate cardiomyocyte contraction and growth. We tested the hypothesis that these differences are attributable to spatial compartmentation of the second messenger cAMP. Using a fluorescent resonance energy transfer (FRET)-based approach, we directly monitored the spatial and temporal distribution of cAMP in adult cardiomyocytes. We...
جهت دستیابی به توسعه پایدار درک تحولات نظام شهری در راستای شناخت روند تغییرات اندازه، شکل و ساختار شهرها در مقیاس زمانی و فضایی امری حیاتی است. توزیع رتبه-اندازه شهری روشی مناسب برای تشخیص و تحلیل توزیع های اندازه شهری در مقیاس فضایی و زمانی می باشند. مدل رشد خودهمبسته فضایی-زمانی توزیع رتبه-اندازه شهری توسط ژو و هریس برای شهرهای تگزاس معرفی شده است. این پژوهش در پی آن است تا متدولوژی ترکیب خود...
The sympathetic nervous system modulates cardiac contractility and rate by activating -adrenergic receptors ( AR) expressed on cardiac myocytes and specialized cells in the sinoatrial node and the conduction system. Recent clinical studies have suggested that -adrenergic receptors also play a role in cardiac remodeling that occurs in the pathogenesis of cardiomyopathy. Both 1 and 2 adrenergic r...
1and 2-adrenergic receptors (AR) regulate cardiac myocyte function through distinct signaling pathways. In addition to regulating cardiac rate and contractility, 1AR and 2AR may play different roles in the pathogenesis of heart failure. Studies on neonatal cardiac myocytes from 1AR and 2AR knockout mice suggest that subtype-specific signaling is determined by subtypespecific membrane targeting ...
در این تحقیق، بطور خاص فرض می شود که کیفیت فرآیند با استفاده از یک پروفایل خطی ساده خودهمبسته از نوع ar(1) مدل می شود. سپس نقطه ی واقعی تغییر در فرآیند بعد از دریافت هشدار از نمودار کنترلt^2 هتلینگ، طراحی شده در فاز 2، با استفاده از سه روش ماکزیمم درستنمایی، خوشه بندی و بدون حذف خودهمبستگی با استفاده از دو نوع شیفت پله ای و تدریجی محاسبه می شود. در نهایت عملکرد سه روش پیشنهادی با استفاده از شبی...
BACKGROUND Cardiopulmonary bypass (CPB), a process routinely used during cardiac surgery, is a potent stimulant to the release of endogenous catecholamines. Hence, we tested the hypothesis that CPB results in myocardial beta-adrenergic receptor (beta AR) desensitization. METHODS AND RESULTS We obtained canine transmyocardial left ventricular biopsies before, during (155 minutes), and after CP...
Anxiety disorders are the most prevalent class of mental illness, yet currently available treatments are often ineffective or inadequate, leaving many patients with lingering symptoms. The serotonin 1A receptor (1AR) has been implicated in the etiology of these disorders, which often show comorbidity with cognitive dysfunction. Mice with the 1AR genetically deleted or "knocked out" (1AKO) durin...
Androgen receptor (AR) signaling is crucial to the development and homeostasis of the prostate gland, and its dysregulation mediates common prostate pathologies. The mechanisms whereby AR regulates growth suppression and differentiation of luminal epithelial cells in the prostate gland and proliferation of malignant versions of these cells have been investigated in human and rodent adult prosta...
The -1 adrenergic receptors ( 1ARs) are critical in sympathetically mediated vasoconstriction. The specific role of each 1AR subtype in regulating vasoconstriction remains highly controversial. Limited pharmacological studies suggest that differential 1AR responses may be the result of differential activation of junctional versus extrajunctional receptors. We tested the hypothesis that the 1BAR...
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