The objective of this study was to assess the physiologically based pharmacokinetic (PBPK) model for predicting plasma concentration-time profiles of orally available cMet kinase inhibitors, (R)-3-[1-(2,6-dichloro-3-fluoro-phenyl)-ethoxy]-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine (PF02341066) and 2-[4-(3-quinolin-6-ylmethyl-3H-[1,2,3]triazolo[4,5-b]pyrazin-5-yl)-pyrazol-1-yl]-ethan...

apoptosis plays an important role in many pathological processes of the central nervous system. the neuroprotective effect of periodic fasting (pf) in contrast to severe fasting or starvation has been suggested. however, these beneficial effects seem to depend on the type and duration of the used feeding protocol. this study was designed to evaluate the effects of different pf protocols on the ...

This paper describes a method for acquiring data for facial movement analysis and implementation in an animated talking head. We will also show preliminary data on how a number of articulatory and facial parameters for some Swedish vowels vary under the influence of expressiveness in speech and gestures. Primarily we have been concerned in expressive gestures and emotions conveying information ...

Objective(s): Paeoniflorin (PF) has anti-oxidation, anti-inflammation, anti-apoptosis, and neuroprotection pharmacological effects against ischemic injury. The aim of the present study was to investigate the neuroprotection mechanisms of PF in cerebral ischemia-reperfusion injury rats.Materials and Methods: We established an animal model of cerebral infarct by occlusion of the middle cerebral a...

an identification of the environmental factors regulating the biosynthesis of antibiotics by fluorescent pseudomonads is an essential step toward improving the ability of these bacteria to control plant pathogens. investigation of nine fluorescent pseudomonads, utilized in growth suppression of rhizoctonia solani, the causal agent of root rot and damping-off of bean plants, by the method of hpl...

A well–known theorem of Schoenberg states that if f(z) generates a PFr sequence then 1/f(−z) generates a PFr sequence. We give two counterexamples which show that this is not true, and give a correct version of the theorem. In the infinite limit the result is sound: if f(z) generates a PF sequence then 1/f(−z) generates a PF sequence.

We consider an asset-liability management (ALM) problem for a defined benefit pension fund (PF). The PF manager is assumed to follow a maximal fund valuation problem facing an extended set of risk factors:  due to the longevity of the    PF members, the inflation affecting salaries in real terms and future incomes, interest rates and market factors affecting jointly the PF liability and asset p...