PURPOSE To compare relative reduction of retinal ganglion cell (RGC) function and retinal nerve fiber layer (RNFL) thickness in early glaucoma by means of steady-state pattern electroretinogram (PERG) and optical coherence tomography (OCT), respectively. METHODS Eighty-four persons with suspected glaucoma due to disc abnormalities (GS: mean age 56.6 +/- 13.8 years, standard automated perimetr...

PURPOSE To characterize differences in retinal ganglion cell (RGC) function in mouse strains relevant to disease models. C57BL/6J (B6) and DBA/2J (D2) are the two most common mouse strains; D2 has two mutated genes, tyrosinase-related protein 1 (Tyrp1) and glycoprotein non-metastatic melanoma protein B (Gpnmb), causing iris disease and intraocular pressure (IOP) elevation after 6 months of age ...

Aim. To evaluate the possible structural and functional changes in the retinal nerve fibre layer (RNFL) and the ganglion cell complex (GCC) of chronic smokers and compare them with those of passive healthy smokers using spectral domain optical coherence tomography (SD-OCT) and pattern electroretinogram (PERG). Materials and Methods. We include 80 active chronic smokers and 80 age- and sex-match...

BACKGROUND The aim of the present study was to investigate the value of pattern visual-evoked potentials (pVEP) and pattern electroretinograms (pERG) in early glaucoma diagnosis. MATERIALS AND METHODS Thirty-eight eyes of 38 patients were included. Patients were classified into normal control (NC) and glaucoma patient (GP) groups. Patients underwent a detailed clinical ophthalmic examination ...

PURPOSE Because glaucomatous visual field loss predominantly occurs in one hemifield, a baseline ratio of pattern electroretinogram (PERG) hemifield amplitudes (upper field:lower field) was determined in normal subjects and then examined in patients with glaucoma. METHODS In 26 normal subjects and eight patients with glaucoma with typical arcuate field loss involving the test area (central 20...

PURPOSE To evaluate the correlation of pattern electroretinogram (PERG), an index of inner retinal function, with confocal scanning laser (CSLO) optic disc structural parameters in ocular hypertension (OHT). METHODS Thirty-four patients with OHT, normal white-on-white (Humphrey 30-2) perimetry, and normal clinical optic discs were examined with PERG and CSLO disc analysis. Two groups of norma...

(referencing the active electrode to the forehead where a small but recordable response is also present) combine to reduce the PERG amplitude. In such situations it is less likely that the spread of potential will be strong enough to be recorded as a referred response. On the other hand, if, in a binocular viewing situation, one records a normal PERG from an eye that has no light perception, th...

OBJECTIVES Visual evoked potentials (VEPs) show abnormal responses in newly-diagnosed insulin-dependent diabetic (IDDM) patients. Electrophysiological methods allow one to dissect and explore different structures contributing to neural conduction in the visual pathways. The aim of our work was to assess whether the VEP abnormalities are due to impaired function of the retinal layers and/or a de...

PURPOSE To better understand the relationship between the amplitude of the pattern electroretinogram (PERG) and visual loss, measured with static automated perimetry. METHODS Transient PERGs were recorded in 15 patients (31-77 years) and 16 normal individuals (26-65 years). An eye was considered to have glaucomatous damage only if there was an abnormal disc, an abnormal 24-2 Humphrey visual f...

PURPOSE To evaluate macular function before and after surgical peeling of idiopathic epimacular membrane (EMM). METHODS Logarithm of the minimal angle of resolution visual acuity and results of focal (central 9 x 9 degrees) electroretinogram (fERG), pattern electroretinogram (pERG), and optical coherence tomography (OCT) assessment of macular volume were evaluated for 22 eyes of 22 patients (...