Creatine kinase (CK; EC 2.7.3.2), although the most commonly measured enzyme for assessing disease activity in polymyositis, is not always a reliable indicator of the extent and severity of myositis. Recently, the CK-MM isoenzyme has been found to undergo post-synthetic modifications upon release into the serum, such that electrophoretically identifiable sub-bands or subisoenzymes--MM1, MM2, an...

Pneumococcal prophages are extremely frequent, but no role in pathogenesis has so far been attributed to them. We isolated a variant of phage MM1, named MM1-1998, from a serotype 24 strain of Streptococcus pneumoniae. We created three isogenic strain pairs (serotypes 3, 4, and 24) that differed only by the lysogenic presence of the MM1-1998 phage and did a phenotypic comparison. Lysogeny led to...

The abundant presence of temperate phages in the chromosomes of clinical isolates of Streptococcus pneumoniae has been well documented. The genome of MM1, a temperate phage of pneumococcus, has been isolated as a DNA-protein complex. The protein is covalently bound to the DNA, was iodinated in vitro with Na125I, and has an Mr of 22,000. Electron microscopy and enzymatic analyses revealed that t...

The temperate phage MM1 forms stable lysogens in Streptococcus pneumoniae. We report here the first characterization of the lysogenic control region in Pneumococcus which contains two functional divergent promoters (P(R) and P(L)). MM1 encodes a 14-kDa cI protein (CI) that appears to be responsible for maintaining the lysogenic state in Pneumococcus since it prevents elongation of the transcrip...

هدف: هدف پژوهش حاضر، بررسی و تبین مهارت‏های مورد نیاز مدیران دوره آموزش عمومی در رهبری مدارس دوران کرونا پساکرونا با توجه به تحولات ایجاد شده اثر این بحران است.مواد روش‏ها: از نظر کاربردی روش، کیفی نوع سنتزپژوهی است. قلمرو اصلی‏ترین منابع گردآوری داده‏ها، پژوهش‏های متعددی است که ارتباط مدرسه مجازی داخل خارج ایران انجام متناسب موضوعی پس رعایت ملاک‏های ورود خروج تعداد 47 نمونه انتخاب شدند. مراحل ...

Microbulbifer sp. CCB-MM1 is a halophile isolated from estuarine sediment of Matang Mangrove Forest, Malaysia. Based on 16S rRNA gene sequence analysis, strain CCB-MM1 is a potentially new species of genus Microbulbifer. Here we describe its features and present its complete genome sequence with annotation. The genome sequence is 3.86 Mb in size with GC content of 58.85%, harbouring 3313 protei...

Both p53-related p63 and c-Myc are transcription factors playing key roles in cell proliferation, survival, development and tumorigenesis. In the present study, we identified that MM1, a c-Myc inhibitor, specifically binds to C-termini of p63α (including ΔNp63α and TAp63α). Further study demonstrates that p63α facilitates MM1 protein degradation via proteasomal pathway, resulting in elevation o...

We report high sensitivity sub-arcsecond angular resolution observations of the massive star forming region DR21(OH) at 3.6, 1.3, and 0.7 cm obtained with the Very Large Array. In addition, we conducted observations of CH3OH 44GHz masers. We detected more than 30 new maser components in the DR21(OH) region. Most of the masers appear to trace a sequence of bow-shocks in a bipolar outflow. The cm...