Layers of Protection Analysis (LOPA) evaluates the sequence of events that first initiate and then propagate to a hazardous event. This semi-quantitative risk assessment technique can expose the role that automation plays in causing initiating events and in responding to the resulting abnormal operation. Automation that is specifically designed to achieve or maintain a safe state of a process i...

A primary objective of the Society for Cardiovascular Angiography and Interventions is to promote excellence in invasive and interventional cardiovascular medicine through physician education and representation, and the advancement of quality standards to enhance patient care. This focus on quality as it applies to the practice of invasive cardiology is unique to SCAI, and the Society has demon...

In order to investigate the contribution of the atrial natriuretic factor (ANF) gene in pathogenesis of essential arterial hypertension (EAH), we analyzed the ScaI gene polymorphism of the ANF gene in a group of children with EAH. Fifty-eight children, aged 8-19 years, with the diagnosis of EAH were included in the association study and were compared to 57 subjects with normal blood pressure (t...

INTRODUCTION Atrial fibrillation (AF) is a frequently encountered complication after coronary artery bypass grafting (CABG), but its underlying mechanisms are still unclear. The natriuretic peptides have been reported as markers for predicting the occurrence of postoperative AF. This study evaluates whether the ScaI ANP gene polymorphisms predict the occurrence of postoperative AF. MATERIAL A...

BACKGROUND Genetic variants related to the natriuretic peptide (NP) system [ScaI mutated allele (A1) of the atrial NP (ANP) gene and the C variant of the natriuretic peptide clearance receptor (NPRC) gene] have been identified as independent risk factors for cardiovascular morbidity and mortality. Despite the importance of NPs in heart failure (HF), the role of these polymorphisms in HF has not...

A method is described for the rapid, economic and non-radioactive examination of DNA samples from hypercholesterolaemic patients for familial defective apolipoprotein B-100, using a modified polymerase chain reaction (PCR) protocol and restriction enzyme isoform genotyping. Because of the high prevalence of familial defective apolipoprotein B-100, which is estimated to be one in 500 in most scr...

Recently, self-curiosity has attracted scholarly attention as a crucial factor in psychological tests and therapy processes. To measure individuals’ degree of self-curiosity, researchers developed the attitude–interest (SCAI) scale; it originated Italy been applied across cultures. This study investigates whether original SCAI scale can be adapted Japan explores characteristics structure Japan....

2610 Introduction In 2007, the Society for Cardiovascular Angiography and Interventions (SCAI) published an Expert Consensus Document titled “The Current Status and Future Direction of Percutaneous Coronary Intervention without On-Site Surgical Backup.” This document summarized the available data on the performance of percutaneous coronary intervention (PCI) without on-site surgery in the Unite...

To investigate mtDNA recombination induced by multiple double strand breaks (DSBs) we used a mitochondria-targeted form of the ScaI restriction endonuclease to introduce DSBs in heteroplasmic mice and cells in which we were able to utilize haplotype differences to trace the origin of recombined molecules. ScaI cleaves multiple sites in each haplotype of the heteroplasmic mice (five in NZB and t...