Abstract: The delay-insensitive minterm synthesis (DIMS) method facilitates a robust two-level asynchronous implementation of dual-rail encoded arbitrary combinational logic. However for multilevel realization, logic decomposition becomes indispensable. In this context, this paper describes an elegant technique of performing quasi-delay-insensitive logic decomposition based on set theoretic pri...

3,3'-Diindolylmethane (DIM), ring-substituted DIMs and 1,1-bis(3'-indolyl)-1-(p-substitutedphenyl)methanes (C-DIMs) inhibit growth of Panc-1 and Panc-28 pancreatic cancer cells. Although DIMs (diarylmethanes) and selected C-DIMs (triarylmethanes), such as the p-t-butyl derivative (DIM-C-pPhtBu), activate the aryl hydrocarbon receptor and peroxisome proliferator-activated receptor gamma, respect...

The Esprit project PRODNET II1 (Production Planning and Management in an Extended Enterprise) had as its main objective the development of a reference architecture and a support infrastructure for Industrial Virtual Enterprises (VEs). The Distributed Information Management system (DIMS) component of the PRODNET architecture supports the complex VE information management requirements and is base...

The activation problem is investigated in two-dimensional nonequilibrium systems. A numerical approach based on dynamic importance sampling (DIMS) is introduced. DIMS accelerates the simulations and allows the investigation to access noise intensities that were previously forbidden. The escape path is observed to be shifted compared to a heteroclinic trajectory calculated in the limit of zero-n...

A numerical approach based on dynamic importance sampling (DIMS) is introduced to investigate the activation problem in two-dimensional nonequilibrium systems. DIMS accelerates the simulations and allows the investigation to access noise intensities that were previously forbidden. A shift in the position of the escape path compared to a heteroclinic trajectory calculated in the limit of zero no...

OBJECTIVE The aim of this study was to examine whether disease-specific quality-of-life measures are independent predictors of mortality in patients with type 2 diabetes. METHODS A cohort of 420 patients with type 2 diabetes was recruited from the outpatient clinic of a medical center. At baseline, the disease-specific measure of the Diabetes Impact Measurement Scales (DIMS) and clinical and ...

Procedures for determination of the residual solvent and volatile impurity content in pharmaceutical products usually rely on dissolution a solvent, followed by headspace-gas chromatography (HS-GC) analysis. Whereas chromatographic systems can utilize wide variety solvents, direct-injection mass spectrometry (DIMS) techniques have fewer options, because elimination column means that instrument ...

In order to compute the packing dimension of orthogonal projections Falconer and Howroyd (1997) introduced a family of packing dimension profiles Dims that are parametrized by real numbers s > 0. Subsequently, Howroyd (2001) introduced alternate s-dimensional packing dimension profiles P-dims and proved, among many other things, that P-dimsE = DimsE for all integers s > 0 and all analytic sets ...

Adenylate kinase (AdK), a phosphotransferase enzyme, plays an important role in cellular energy homeostasis. It undergoes a large conformational change between an open and a closed state, even in the absence of substrate. We investigate the apo-AdK transition at the atomic level both with free-energy calculations and with our new dynamic importance sampling (DIMS) molecular dynamics method. DIM...

BACKGROUND Metabolic syndrome (MetS) is a constellation of factors including abdominal obesity, hyperglycemia, dyslipidemias, and hypertension that increase morbidity and mortality from diabetes and cardiovascular diseases and affects more than a third of the population in the US. Clozapine, an atypical antipsychotic used for the treatment of schizophrenia, has been found to cause drug-induced ...