Approximately 5-10% of all thyroid cancers are medullary thyroid carcinomas (MTC). MTC is mainly sporadic in nature, but 20-30% of cases are hereditary. Genetic testing for hereditary MTC is very important for the patient and his family, but the patients must be receiving appropriate genetic counseling. About 98% of patients with hereditary MTC have germline mutations in exons 10, 11, 13, 14, 1...

OBJECTIVE To evaluate the usefulness of preoperative serum calcitonin (sCT) in patients with nodular disease without suspicion of medullary thyroid carcinoma (MTC) in history or cytology. PATIENTS AND METHODS sCT was measured before thyroidectomy in 494 patients with nodular disease who had no family history of MTC or multiple endocrine neoplasia type 2, and no cytological suspicion of MTC. ...

Machine-type communication (MTC) is the key technology to support data transfer among devices (sensors and actuators). Cellular communication technologies are developed mainly for “human-type” communications, while enabling MTC with cellular networks not only improves the connectivity, accessibility, and availability of an MTC network but also has the potential to further drive down the operati...

All of the cases of medullary thyroid carcinoma (MTC) express the RET receptor tyrosine kinase. In essentially all of the hereditary cases and 40% of the sporadic cases of MTC, the RET kinase is constitutively activated by mutation. This suggests that RET may be an effective therapeutic target for treatment of MTC. We show that the indolocarbazole derivatives, CEP-701 and CEP-751, inhibit RET i...

Medullary thyroid carcinoma (MTC) is a rare tumour arising from neural crest-derived parafollicular C-cells. Metastatic MTC patients are incurable because the cancer does not respond to radiotherapy or chemotherapy. The REarranged during Transfection (RET) proto-oncogene plays a key role in the development of MTC. However, one-half of the sporadic MTC do not carry RET mutations. Mice models and...

The concurrent data transmission from massive machine type communications (MTC) devices within a short time period makes the traffic flow of MTC more bursty. The classic Markovian traffic models under the assumption of Poisson arrival, whose inter-arrival time (IAT) is a negative exponentially distributed random variable with infinite support range, are no longer suitable for this situation. Be...

The statistical feature of occurrence of multiple tropical cyclone (MTC) events in the western North Pacific (WNP) is examined during summer (June–September) for the period of 1979–2006. The number of MTC events ranged from one to eight per year, experiencing a marked interannual variation. The spatial distance between the TCs associated with MTC events is mostly less than 3000 km, which accoun...