625 IRAQ, Afghanistan, Kosovo, Bosnia, Somalia, Mozambique, Indonesia – all countries that have suffered or are currently suffering from the effects of conflict or natural disaster, and all countries where veterinary expertise has been required. While media images from such areas primarily focus on the human cost, livestock and draught animals are often an essential part of the lives of the peo...

1. Proof. (a) Let x ∈ [0, 1] and δ > 0, we want to show that there exist n such that nλ mod 1 ∈ (x−δ, x+δ), for which it suffices to show that there exists n0 and y ∈ (−δ, δ) such that n0λ ≡ y (mod 1). Then take n to be an appropriate multiple of n0. To prove the reduced proposition, choose m such that 10−m < δ. Note that there exist n1 < n2 such that (n1λ mod 1) and (n2λ mod 1) have the same f...

MicroRNAs (miRNAs) play a critical role in controlling tumor invasion and metastasis via regulating the expression of a variety of targets, which act as oncogenes or tumor suppressor genes. Abnormally expressed miR-625-3p has been observed in several types of human cancers. However, the molecular mechanisms of miR-625-3p-mediated tumorigenesis are largely elusive. Therefore, the aim of this stu...

Imprinted genes show differential expression between maternal and paternal alleles as a consequence of epigenetic modification that can result in ‘parent-of-origin’ effects on phenotypic traits1. There is increasing evidence from mouse and human studies that imprinted genes may influence behavior and cognitive functioning2. Previous work in girls with Turner syndrome (45,XO) has suggested that ...

The 2.05-Å resolution structure of the aquaglyceroporin from the malarial parasite Plasmodium falciparum (PfAQP), a protein important in the parasite’s life cycle, has been solved. The structure provides key evidence for the basis of water versus glycerol selectivity in aquaporin family members. Unlike its closest homolog of known structure, GlpF, the channel conducts both glycerol and water at...

Dysregulated microRNA (miR)-625 expression has been observed in several kinds of cancer. MicroRNAs are important factors in the development and progression of malignant melanoma, though the clinical significance and function of miR-625 in human malignant melanoma remain unclear. Levels of miR-625 expression were therefore determined in 36 pairs of malignant melanoma and adjacent non-tumor tissu...

Oxaliplatin resistance in colorectal cancers (CRC) is a major medical problem, and predictive markers are urgently needed. Recently, miR-625-3p was reported as a promising predictive marker. Herein, we show that miR-625-3p functionally induces oxaliplatin resistance in CRC cells, and identify the signalling networks affected by miR-625-3p. We show that the p38 MAPK activator MAP2K6 is a direct ...

5. Principal Investigator: Shashi Shekhar, Professor, University of Minnesota, Department of Computer Science and Engineering, 4-192 EE/CS Building 200 Union Street SE, Minneapolis, MN 55455, Phone: (612) 625-4012 Fax: (612) 625-0572, Email: [email protected] Alternate contact information. Angie Vail, Grants Management Coordinator, Department of Computer Science and Engineering. Phone:(612) 62...