Introduction: In 2022, the Harvard/Beth Israel Deaconess Disaster Medicine Fellowship conducted a full-scale exercise (FSX) with dual mission of 1) training Fellows (DMFs) in design, planning, and execution, 2) expanding local first responder experience pediatric casualties mixed-method terrorist attack. Method: Project PUNCH (Preparedness for Uncertain Novel Chemical Hazards) was planned two s...

OBJECTIVE To assess the mutational and clinical spectrum of spatacsin associated with autosomal recessive hereditary spastic paraplegia (ARHSP) with thin corpus callosum (TCC). METHODS A retrospective study was carried out at King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia from February 2008 until March 2011. Four unrelated Saudi Arabian families with ARHSP-TCC were ...

Hepatocytes provide an integrated model to study drug metabolism and disposition. As a result of a loss of polarity or a significant decrease in the expression of enzymes and transporters, suspended and sandwich-cultured hepatocytes have limitations in determining hepatocellular drug concentrations. Underprediction of the extent of glucuronidation is also a concern for these hepatocyte models. ...

Using next-generation sequencing technology, we describe the complete mitochondrial genomes for 5 Australian passerine birds (Epthianura albifrons, Petroica phoenicea, Petroica goodenovii, Petroica boodang, and Eopsaltria australis). We successfully assemble each mitogenome de novo using just 1/8th of a Roche GL FSX 454 pyrosequencing plate. From the assembled mitogenomes, we identify 2 differe...

The acridinone derivates 5-dimethylaminopropylamino-8-hydroxytriazoloacridinone (C-1305) and 5-diethylaminoethylamino-8hydroxyimidazoacridinone (C-1311) are promising antitumor agents with high activity against several experimental cellular and tumor models and are under evaluation in preclinical and early phase clinical trials. Recent evidence from our laboratories has indicated that both comp...

The potato psyllid, Bactericera cockerelli (šulc), has been detrimental to potato, tomato, and other solanaceous crop production in many countries. Management of B. cockerelli is dominated by frequent insecticide applications, but other approaches need consideration, including biological control. The sole arrhenotokous ectoparasitoid of nymphal potato psyllids is Tamarixia triozae (Burks) (Hyme...

larger scale than that for which their estimated effects were originally obtained, occurs across many different applications, programs, and disciplines. Economic models of scale-up, which are the concern of this chapter, have focused on particular types of scale-up effects that occur frequently in interventions where economic outcomes are the major interest and where program beneficiaries—in th...