The serine protease HtrA2/Omi is released from the mitochondria into the cytosol following apoptosis stimuli, leading to the programmed cell death in caspase-dependent and -independent manners. The function of HtrA2/Omi closely relates to its protease activity, which is required for cleavage of its substrate such as the members of the X-linked inhibitor of apoptotic protein family. However, the...

HtrA2/Omi is a mitochondrial serine protease that is released into the cytosol and promotes apoptotic processes by binding to several members of the inhibitors of apoptosis protein family. HtrA2/Omi knockout mice show a parkinsonian phenotype, and mutations in the gene encoding HtrA2/Omi have been identified as susceptibility factors for Parkinson disease (PD). These results suggest that HtrA2/...

The serine protease HtrA2/Omi, a regulator of apoptosis, is localized in mitochondria and is released into the cytosol after apoptotic stimuli. Previous studies demonstrate that Omi/HtrA2 is associated with a variety of malignancies. In the present study, we analyzed the expression of Omi/HtrA2 in 52 epithelial ovarian carcinoma (EOC) tissues and paired corresponding adjacent non-tumor tissues ...

[1] The Ozone Monitoring Instrument (OMI) project team uses two total ozone retrieval algorithms in order to maintain the long-term record established with Total Ozone Mapping Spectrometer (TOMS) data as well as to improve the ozone column estimate using the hyperspectral capability of OMI. The purpose of this study is to assess where the algorithms produce comparable results and where the diff...

[1] In this paper we present validation results of the total ozone column data products of the Ozone Monitoring Instrument (OMI) on board the NASA EOS-AURA satellite through comparisons with ground-based observations by Dobson and Brewer spectrophotometer instruments. Quality-controlled and archived total ozone column data from these ground-based instruments located at stations worldwide have b...

[1] Verification of the geolocation assigned to individual ground pixels as measured by the Ozone Monitoring Instrument (OMI) aboard the NASA EOS-Aura satellite was performed by comparing geophysical Earth surface details as observed in OMI false color images with the high-resolution continental outline vector map as provided by the Interactive Data Language (IDL) software tool from ITT Visual ...

The proteasome inhibitor bortezomib is associated with the development of peripheral neuropathy in patients, but the mechanism by which bortezomib can induce peripheral neuropathy is not fully understood. One study suggested that off-target inhibition of proteases other than the proteasome, particularly HtraA2/Omi, may be the underlying mechanism of the neuropathy. The same study also concluded...

Abnormal cellular metabolism is a hallmark of cancer, yet there is an absence of quantitative methods to dynamically image this powerful cellular function. Optical metabolic imaging (OMI) is a noninvasive, high-resolution, quantitative tool for monitoring cellular metabolism. OMI probes the fluorescence intensities and lifetimes of the autofluorescent metabolic coenzymes reduced NADH and flavin...

In this paper we report on the progress achieved within the framework of the joint ESA KNMI NIVR Calibration and Validation Announcement of Opportunity for the Ozone Monitoring Instrument aboard the NASA EOS Aura satellite. This OMI AO effort has rendered a wealth of validation results and scientific insights. Herein this contribution only a selection of the validation results is presented. OZO...

HtrA serine peptidase 2 (HtrA2), also named Omi, is a pro-apoptotic protein that exhibits dramatic changes in expression levels in a variety of disorders, including ischemia/reperfusion injury, cancer, and neurodegeneration. In our study, Omi/HtrA2 protein levels were high in the heart, brain, kidney and liver, with elevated heart/brain expression in aging mice. A similar expression pattern was...