OBJECTIVE To investigate liver lobe volumes and the ratios of liver lobe volumes to spleen volume measured with magnetic resonance imaging (MRI) for quantitatively monitoring and staging liver fibrosis. METHODS Animal study was approved by Institutional Animal Care and Use Committee. Sixteen minipigs were prospectively used to model liver fibrosis, and underwent abdominal gadolinium-enhanced ...

Lettuce mosaic, caused by the potyvirus LMV, is a serious viral disease of lettuce crops world-wide. Beside seed control, one of the leading strategies to control LMV is the use of the recessive resistance genes mo11 and mo12. In an attempt to characterize the functional role of the translation initiation factor eIF4E in lettuce susceptibility to LMV, we cloned Ls-eIF4E cDNAs from a collection ...

Objective: In this study, a RP-HPLC (stability-indicating) based assay method for the estimation of doravirine (DRV), tenofovir disoproxil fumarate (TFF) and lamivudine (LMV) simultaneously in tablets was described.
 Methods: The simultaneous analysis DRV, TFF LMV done with HPLC system (Agilent 1100 series) Luna Phenomenex C18 (250 mm × 4.6 5 μ) column isocratic mobile phase (35% volume ra...

a Clermont Université, Université Blaise Pascal, Laboratoire Magmas et Volcans, BP 10448, F-63000 Clermont-Ferrand, France b CNRS, UMR 6524, LMV, F-63038 Clermont-Ferrand, France c IRD, R 163, LMV, F-63038 Clermont-Ferrand, France d Institut de Physique du Globe de Paris, Equipe Sismologie, CNRS-UMR 7154, Université Paris Diderot 7, PRES Sorbonne Paris Cité, Paris, France e California Institute...

Marul ülkemizde birçok bölgede üretimi yapılan önemli bir sebze türüdür. üretiminde sorun oluşturan çok sayıda patojen bulunmakta olup bunlardan biri de mozaik virüsü (Lettuce mosaic virus, LMV)’dür. Bu virüsün ki varlığı farklı bölge ve illerden bildirilmiştir. Hastalığın tanısı teşhisine yönelik çalışma yapılmış olmasına rağmen ülkemiz LMV izolatlarının tüm genom dizilimlerinin belirlenmesine...

BACKGROUND The purpose was to compare the efficacy between tenofovir disoproxil fumarate (TDF) and lamivudine (LMV) in children with nucleos(t)ide-naive chronic hepatitis B (CHB) infection. Patients with CHB were treated with TDF in the immune-reactive phase and compared with a historical control group of patients treated with LMV before the TDF era. METHODS Hepatitis B virus (HBV) DNA titer ...

BACKGROUND HBV reactivation is associated with high mortality rates in hematopoietic stem cell transplantation (HSCT) and prophylactic lamivudine (LMV) treatment is suggested to prevent this phenomenon. However, the duration of LMV treatment in HSCT patients is not fully defined and the time of immune recovery is considered the best parameter for a drug to be safely interrupted. In patients und...

BACKGROUND Lamivudine (LMV), as the preferred oral drug for use in treatment of HBV, always results in development of resistance mutations after long-term treatment. In this study we investigated chronic hepatitis B (CHB) patients in southern China to determine whether different HBV genotypes affect the incidence of LMV resistance mutations. MATERIAL/METHODS The study recruited 185 CHB patien...

BACKGROUND The antiviral effect of HBV in different nucleos (t) ide analogues is still not well known. This study was conducted to compare the effectiveness of lamivudine (LMV), adefovir dipivoxil (ADV), telbivudine (LdT), and entecavir (ETV) monotherapy in chronic HBeAg-negative hepatitis B patients with medium load of HBV DNA. MATERIAL AND METHODS The effective data of 207 patients treated by...

Intraerythrocytic Plasmodium falciparum exports proteins to the cytosol and to the plasma membrane of the host cell. We here present data revealing the existence of a unique common pathway for the surface bound traffic of the clonally variant antigens, repeated-interspersed-antigen (RIFINS) and P. falciparum erythrocyte-membrane-protein-1 (PfEMP1). RIFIN- and PfEMP1-specific antibodies were fou...