Sirtuins are NAD(+)-dependent protein deacylases that are conserved in all domains of life and are involved in diverse cellular processes, including control of gene expression and central metabolism. Eukaryotic sirtuins have N-terminal extensions that have been linked to protein multimerization and cellular localization. Here the first evidence of sirtuin isoforms in bacteria is reported. The e...

Results The overall failure rate was 31% after bracing and 52% after observation. Age, gender, Risser, Sanders’ digital maturity stage (DMS), curve type and Cobb angle were all associated with outcome. DMS stages were more predictive of failure than Risser grade, even with age in the model. The best-fitting model included the DMS (1-2, 3, or 4+), Cobb angle, and treatment (p<0.0001, c statistic...

Matthew Cobb is Senior Lecturer in Animal Behaviour at the University of Manchester. He earned his PhD in Psychology and Genetics from the University of Sheffield in 1984, and spent most of his career in France. He specialises in insect behaviour, with a focus on chemical communication and the olfactory responses of Drosophila larvae. He recently co-edited Insect Taste and has translated a numb...

In order to study the effects of various levels of protein in diet based on total and digestible amino acids on performance and carcass traits of broilers, an experiment was conducted as a completely randomized design with 288 broiler chicks from Cobb 500 strain in 6 treatments, each treatment consist of 3 replicates with 16 chicks per replicate. Treatments were the diets as follow: 1) diet for...

BACKGROUND Supine imaging modalities provide valuable 3D information on scoliotic anatomy, but the altered spine geometry between the supine and standing positions affects the Cobb angle measurement. Previous studies report a mean 7°-10° Cobb angle increase from supine to standing, but none have reported the effect of endplate pre-selection or whether other parameters affect this Cobb angle dif...

The silent information regulator (Sir2) family proteins are NAD+-dependent deacetylases. Although a few substrates have been identified, functions of the bacteria Sir2-like protein (CobB) still remain unclear. Here the role of CobB on Escherichia coli chemotaxis was investigated. We used Western blotting and mass spectrometry to show that the response regulator CheY is a substrate of CobB. Surf...

UNLABELLED Spinal curvatures alter measured stature and may influence the evaluation of skeletal maturity and growth based on stature measurements. METHODS A dataset of calibrated measurements of vertebral positions of 407 radiographs in the frontal plane, together with clinically measured Cobb angles was used to determine the difference between spinal length and spinal height ('height loss')...

Athens Canadian Random Bred (ACRB) chickens, a 1955 meat-type control strain, were incubated with the 2013 Cobb 500 broiler to determine differences in egg composition, conductance values, incubation duration, hatch performance, and yolk utilization. Unincubated ACRB eggs had greater percentage solids than Cobb 500 eggs. The ACRB eggs had a greater solid portion as yolk, whereas the Cobb 500 de...