BACKGROUND The human retinoblastoma susceptibility gene encodes a nuclear phosphoprotein RB, which is a negative regulator of cell proliferation. The growth suppression function of RB requires an evolutionarily conserved A/B domain that contains two distinct peptide-binding pockets. At the A/B interface is a binding site for the C-terminal trans-activation domain of E2F. Within the B-domain is ...

As a frontier issue of physics and material, the structures related properties borides have been extensively investigated in fundamental science. The search for pressure-induced stable compounds has become feasible approach to acquire that are inaccessible at atmospheric pressure. Combined with state-of-the-art swarm intelligence structure prediction first-principles calculations, we systematic...

Abstract In this paper, we will investigate some topological properties of Rb set of all bounded generalized Rhally matrices given by b sequences in H. We will show that Rb is closed subspace of B (H) and we will define an operator from T to Rb and show that this operator is injective and continuous in strong-operator topology.

The cell transmission model of a freeway is used to compare four congestion-reducing schemes: (R) ramp control only; (T) one lane is tolled and ramps are uncontrolled; (B) bottlenecks are tolled and ramps are uncontrolled; and (RB) ramps are controlled and bottlenecks are tolled. In the base case, ramps are uncontrolled and there are no tolls. It is found that (T) is inefficient and may leave a...

In this paper we consider several constructions which from a given B-product ∗B lead to another one ∗̃B . We shall be interested in finding what algebraic properties of the ring RB = 〈CN, +, ∗B 〉 are shared also by the ring RB̃ = 〈C N, +, ∗B 〉. In particular, for some constructions the rings RB and RB̃ will be isomorphic and therefore have the same algebraic properties. §

Progression through the cell cycle is dependent on the sequential expression of cyclins, which combine with cyclin-dependent kinases (cdks) to form active kinases. The transition from G1 to S phase is dependent on D cyclins in complex with cdk4 or cdk6 and cyclin E complexed with cdk2. One target of G1 cyclins is the retinoblastoma susceptibility protein (Rb). Rb is a transcriptional repressor ...

Inactivation of the retinoblastoma tumor-suppressor gene (RB-1) has been associated with tumorigenicity in various human malignancies. In chronic lymphoid leukemias of B-cell origin (B-CLL) an involvement of RB-1 has been suggested based on cytogenetic data. We examined RB-1 and its chromosomal locus 13q14 in 35 cases of B-CLL by dual-color in situ hybridization to interphase nuclei and by G-ba...

In this paper we propose a new type of random CSP model, called Model RB, which is a revision to the standard Model B. It is proved that phase transitions from a region where almost all problems are satis able to a region where almost all problems are unsatis able do exist for Model RB as the number of variables approaches in nity. Moreover, the critical values at which the phase transitions oc...

Abstract For the ternary systems, Rb 2 SO 4 – CaSO H O and Cs O, solubility data have been determined at ambient temperatures (22 25 °C). In both gypsum is found as stable -phase in presence of low alkali metal sulfate concentrations. addition, two double salts exist Rb-system: Rb-disalt (Rb ·2CaSO ) Rb-syngenite ·CaSO ·H O) addition to . Rb-syngenite, crystal structure was by single analysis (...