Elucidation of the biological role of linker histone (H1) and heterochromatin protein 1 (HP1) in mammals has been difficult owing to the existence of a least 11 distinct H1 and three HP1 subtypes in mice. Caenorhabditis elegans possesses two HP1 homologues (HPL-1 and HPL-2) and eight H1 variants. Remarkably, one of eight H1 variants, HIS-24, is important for C. elegans development. Therefore we...

conclusions health providers should improve the qol in the elderly by facilitating hpl through health-promoting interventions, which will maintain and increase physical activity, stress management, and spiritual growth. background as individuals live a longer life, health-promoting lifestyle (hpl) becomes even more essential, particularly with regard to maintaining functional independence and i...

One goal of the VaNTH Engineering Research Center is to estimate the effects of the “value added” to bioengineering student learning as a result of “How People Learn” (HPL) framework interventions. A necessary step in that process is to assess pedagogical differences in both lecture-based and HPL-oriented courses. Data from 28 bioengineering courses, over five semesters, were analyzed using a n...

The biochemical and biologic properties of a purified disulfide conjugate of diphtheria toxin fragment A and human placental lactogen (toxin A-hPL) have been studied by (a) assaying the ADP-ribosyltransferase activity of the intact conjugate, (b) assaying the binding of the intact conjugate to mammary gland plasma membrane lactogenic receptors, and (c) assaying the effect of the conjugate on th...

A messenger activity for HPL was identified in normal human term placentas. The mRNA was translated in rabbit reticulocyte cell-free system. The HPL synthesized was quantified by a specific immunoprecipitation and further identified by electrophoresis on sodium dodecyl sulfate polyacrylamide gel. The HPL synthesized in the reticulocyte lysate exhibited a molecular weight between 20,000 and 22,0...

We previously isolated a naturally occurring dimer of human placental lactogen (hPL) and showed that it was linked by one or more disulfide bonds. Monomeric hPL is a 191-amino acid peptide with two disulfide bonds, one between residues 54 and 165 and the other between 182 and 189. The present studies were designed to determine the location of the disulfide bonds in dimeric hPL and to relate thi...

This study was aimed to develop the haloperidol (HPL) loaded solid lipid nanoparticles (SLNs) for brain targeting through intranasal route. SLNs were fabricated by emulsification diffusion technique using glyceryl behenate as and tween 80 a surfactant. evaluated particle size, zeta potential, structure, entrapment efficiency, state characterization differential scanning calorimetry (DSC), in-vi...

This paper describes our effort to enhance the performance of the AORSA fusion energy simulation program through the use of High Performance LINPACK (HPL) benchmark, commonly used in ranking the top 500 supercomputers. The algorithm used by HPL, enhanced by a set of tuning options, is more effective than that found in the ScaLAPACK library. Retrofitting these algorithms, such as look-ahead proc...

The acute metabolic effects and disposition of human placental lactogen (HPL) have been studied in 15 men and 8 women during continuous intravenous infusions. The mean plasma half-life, metabolic pool size, and turnover rate of HPL are comparable to the values previously reported for human growth hormone (HGH). From the data presented, we calculate that the placenta secretes approximately 290 m...

background and aim: health-promoting lifestyle (hpl) is one of the main criteria which determine health and underlying factors preventing the health-threatening factors. hpl includes six dimensions of spiritual growth, health responsibility, nutrition, stress management, interpersonal relations, and physical activity. considering the importance of students’ health, both at individual and social...