Rhabdoid tumor of the kidney (RTK) is a rare malignancy in infancy. Central nervous system involvement in RTK is already known. However, solitary spinal metastasis in RTK has been hardly reported. The authors report a case of metastatic RTK to spine causing paraplegia in an 8-month-old girl. Since the patient was young, the diagnosis of spine metastasis was delayed until paraplegia was seen aft...

One of the recent breakthroughs in cancer research is the identification of activating mutations in various receptor tyrosine kinase(RTK) pathways in many cancers including colorectal cancer(CRC). We hypothesize that, alternative to mutations, overexpression of various oncogenic RTKs may also underpin CRC pathogenesis, and different RTK may couple with distinct downstream signaling pathways in ...

PURPOSE Receptor tyrosine kinase AXL (RTK-AXL) is regarded as suitable target in glioma therapy. Here we evaluate the anti-tumoral effect of small molecule inhibitor BMS-777607 targeting RTK-AXL in a preclinical glioma model and provide evidence that RTK-AXL is expressed and phosphorylated in primary and recurrent glioblastoma multiforme (GBM). EXPERIMENTAL DESIGN We studied the impact of BMS...

Parent and adolescent (M = 15.7 years) beliefs regarding parents’ right to know (RTK) about adolescents’ activities were examined in 174 middle-class U.S. families. Mean differences and associations with latent changes in teens’ concealment were assessed. RTK was greatest about risky prudential activities, least for personal activities for parents and romantic activities for teens, and higher f...

Network RTK (Real-Time Kinematic) is a technology that is based on GPS (Global Positioning System) or more generally on GNSS (Global Navigation Satellite System) measurements to achieve centimeter-level accuracy positioning in real-time. Reference station placement is an important problem in the design and deployment of network RTK systems as it directly affects the quality of the positioning s...

RTKLIB is an open source program package for RTK-GPS developed by the authors. RTKLIB is a compact and portable program library written in C to provide a standard platform for RTK-GPS applications. The library implements fundamental navigation functions and carrier-based relative positioning algorithms for RTK-GPS with integer ambiguity resolution by LAMBDA. RTKLIB also supports data communicat...

The herpes simplex virus thymidine kinase/ganciclovir (HSV TK/GCV) system is one of the best studied cancer suicide gene therapy systems. Our previous study showed that caspase 3 expression was upregulated and bladder tumor growth was significantly reduced in rats treated with a combination of Bifidobacterium (BF) and HSV TK/GCV (BF-rTK/GCV). However, it was raised whether the BF-mediated recom...

Multiple myeloma (MM) is a plasma cell disorder that is characterized by a great genetic heterogeneity. Recent next generation sequencing studies revealed an accumulation of tumor-associated mutations in receptor tyrosine kinases (RTKs) which may also contribute to the activation of survival pathways in MM. To investigate the clinical role of RTK-mutations in MM, we deep-sequenced the coding DN...

The single base real-time kinematic (RTK) positioning technique is distance-dependent in terms of accuracy and reliability of the integer ambiguity resolution. The Network RTK (NRTK) technique has been developed to overcome this limitation, so is able to be used over longer distances than is possible with single base RTK whilst maintaining centimetre-level accuracy. This multiple reference stat...