Transgenic overexpression of the Notch1 intracellular domain inhibits osteoblast differentiation and causes osteopenia, and inactivation of Notch1 and Notch2 increases bone volume transiently and induces osteoblastic differentiation. However, the biology of Notch is cell-context-dependent, and consequences of Notch activation in cells of the osteoblastic lineage at various stages of differentia...

The Rapid Office Strain Assessment (ROSA) was designed to quickly quantify risks associated with computer work and to establish an action level for change based on reports of worker discomfort. Computer use risk factors were identified in previous research and standards on office design for the chair, monitor, telephone, keyboard and mouse. The risk factors were diagrammed and coded as increasi...

Apoptosis is one way of controlling immune responses, and a variety of immunosuppressive drugs suppress harmful immune responses by inducing apoptosis of lymphocytes. In this study we observed that rosmarinic acid, a secondary metabolite of herbal plants, induced apoptosis in an p56(lck) (Lck)-dependent manner; Lck(+) Jurkat T cells undergo apoptosis in response to rosmarinic acid (RosA) treatm...

Nature of Work: ‘Santa Rosa’ magnolia, a selection of the native Magnolia virginiana L. (Sweet Bay magnolia) introduced by Woodlanders Nursery, Aiken, S.C. in 1979, is an upright, evergreen tree with an open growth habit. Leaves of ‘Santa Rosa’ are larger than the species as are the lemon scented flowers (Raulston, personal communication). These attributes along with height growth that approach...

Rosmarinic acid (RosA) is a water-soluble polyphenol, which can be isolated from many herbs such as orthosiphon diffuses and rosmarinus officinalis. Previous studies have shown that RosA possesses various biological properties. In this study, we investigate the anti-osteoarthritic effects of RosA in rat articular chondrocytes. Chondrocytes were pre-treated with RosA, followed by the stimulation...

ROSA is an e-learning system, which enables the creation, storage, reuse and management of Learning Objects (LOs). LO is a collection of reusable material used to support learning, education, or training. However, since ROSA is still a centralized system, it does not provide yet a complete integration of LOs created in local ROSAs of other institutions. This paper presents the evolution of ROSA...

BACKGROUND Diabetes mellitus is one of the most common endocrinal disorders and medicinal plants continue to play an important role in the management of this disease. In this study, Rosa canina was investigated for the antioxidant and α-amylase inhibition activities. MATERIALS AND METHODS Methanolic extract of Rosa canina was investigated for its potential antioxidant activity. The extracts' ...

Learning Content Management Systems (LCMS) store and manage e-learning content and play an important role in the development of Distance Learning technology. ROSA (Repository of Objects with Semantic Access) is a LCMS that provides the creation, storage, reuse, retrieval and management of learning objects (LO). In ROSA, course structure and content (LOs) are organized according to Conceptual Ma...