In this thesis, we develop the theory of High Dimensional Consensus (HDC), a general class of distributed algorithms in large-scale networks. HDC relies only on (i) local information, (ii) local communication, and (iii) low-order computation, and, hence, is ideally suited to implement network tasks under resource constraints, e.g., in sparse networks with a limited computation budget. HDC, in g...

Mature 53 kDa histidine decarboxylase (HDC) peptide is produced from a precursor 74 kDa peptide. The mechanism of specific cleavage by processing enzyme is unknown. Using the recombinant mouse 74 kDa HDC, we found that porcine pancreatic elastase specifically converted the inactive 74 kDa HDC to its active form of 53 kDa HDC.

Prohistidine d carboxylase, previously demonstrated only in mutant 3 of Lactobacillus 30a (P. A. Recsei and E. E. Snell(1973) Biochemistry 12,365-371), is also formed (together with active enzyme) during incubation of nongrowing cultures of wild type Lactobacillus 30a with histidine. Activation of purified wild type proenzyme occurs about three times faster than that of the mutant 3 proenzyme...

Heterogeneous Distributed Computing (HDC) system consists of Workstations (WSs) and Personal Computers (PCs). In HDC system, each WS/PC may have different processor and performance. In order to take advantage of this diversity of processing power of a system, an effective task partitioning, scheduling, and load balancing are needed to get the optimum performance. This paper examines the effecti...

KLF4 is a transcription factor that is highly expressed in the gastrointestinal tract. Previously we have demonstrated that KLF4 represses HDC promoter activity in a gastric cell line through both an upstream Sp1 binding GC box and downstream gastrin responsive elements. However, the mechanism by which KLF4 inhibits HDC promoter is not well defined. In the current study, by using yeast two-hybr...

Breast cancer has become the leading indication for high-dose chemotherapy (HDC) with autologous stem cell rescue (ASCR) in North America. The rapid increase in HDC/ASCR for breast cancer has been driven by belief in the response rates and survival times demonstrated in phase II studies, which have been higher than that of historical controls. However, there is a growing body of data to suggest...

The effects of different types of stress (water bathing, cold, restraint, and prolonged walking) on histidine decarboxylase (HDC) activity in masseter, quadriceps femoris, and pectoralis superficial muscles, and in the stomach were examined in mice. All of these stresses elevated gastric HDC activity. Although water bathing, in which muscle activity was slight, was sufficiently stressful to pro...

There are two very different approaches to laryngeal echolocation in bats. Although most bats separate pulse and echo in time by signalling at low duty cycles (LDCs), almost 20% of species produce calls at high duty cycles (HDCs) and separate pulse and echo in frequency. HDC echolocators are sensitive to Doppler shifts. HDC echolocation is well suited to detecting fluttering targets such as fly...

The majority of adult organs of a holometabolic insect like Drosophila melanogaster are derived from specific imaginal cells. These cells differ from their larval equivalents in many important cellular characteristics, ranging from the nature of the cell cycle to the timing and pattern of cellular differentiation. Here we describe the cellular, molecular and genetic characterization of a gene, ...

Histamine has pleiotropic pathophysiological effects, but its role in myocardial infarction (MI)-induced cardiac remodeling remains unclear. Histidine decarboxylase (HDC) is the main enzyme involved in histamine production. Here, we clarified the roles of HDC-expressing cells and histamine in heart failure post-MI using HDC-EGFP transgenic mice and HDC-knockout (HDC-/-) mice. HDC+CD11b+ myeloid...