The yeast Dsl1p vesicle tethering complex, comprising the three subunits Dsl1p, Dsl3p, and Tip20p, is stably associated with three endoplasmic reticulum-localized Q-SNAREs and is believed to play a central role in the tethering and fusion of Golgi-derived COP-I transport vesicles. Dsl1p also interacts directly with COP-I subunits. We now show that binding of Dsl1p to COP-I subunits involves bin...

Extensive variations of colloid osmotic pressure (COP) measured in the priming as well as during infant cardiopulmonary bypass motivated us to audit clinical and laboratory data to identify the risk factors for low COP at the end of bypass. Data of 73 consecutive infant patients with body weight <10 kg, who underwent elective, first time open-heart surgery between March 2005 and December 2006 w...

The activity of copolymer 1 (Cop 1, Copaxone, glatiramer acetate) in suppressing experimental autoimmune encephalomyelitis (EAE) and in the treatment of multiple sclerosis patients when injected parenterally has been extensively demonstrated. In the present study we addressed the question of whether Cop 1 can induce oral tolerance to EAE similar to myelin basic protein (MBP). We now have demons...

In this paper, we have developed an efficient method for real time computation of Center of Pressure (CoP) sway area using a fast search and sort based on a numerical approximation of the Green-Gauss method. In addition, we investigated the correlations among the velocity, acceleration, path length, sway area, and mean frequency of CoP signals during quiet standing in healthy children and in ch...

OBJECTIVE The colloid osmotic pressure (COP) of plasma and interstitial fluid play important roles in transvascular fluid exchange. COP values for monitoring fluid balance in healthy and sick children have not been established. This study set out to determine reference values of COP in healthy children. MATERIALS AND METHODS COP in plasma and interstitial fluid harvested from nylon wicks was ...

The game of cops and robber is a two-player game, played on a graph, between a cop and a robber. To begin the game, the cop and robber each choose a vertex to occupy, with the cop choosing first. Play then alternates between the cop and the robber, with the cop moving first; on a turn a player may move to an adjacent vertex or stay still. If the cop and robber ever occupy the same vertex, the c...

El cambio climático ha sido un tema pertinente en las últimas décadas desde que los países se han concientizado del daño sus industrias le ocasionan al medio ambiente. Gracias a este proceso de concientización ambiental surgido puntos encuentro internacionales pretenden ser pioneros la formulación políticas alineadas desarrollo sostenible, como Conferencia Partes (COP). Este trabajo tiene objet...

We isolated a novel yeast α-COP mutant, ret1-3, in which α-COP is degraded after cells are shifted to a restrictive temperature. ret1-3 cells cease growth at 28°C and accumulate the ER precursor of carboxypeptidase Y (p1CPY). In a screen for high copy suppressors of these defects, we isolated the previously unidentified yeast ε-COP gene. ε-COP (Sec28p) overproduction suppresses the defects of r...