VKORC1 (vitamin K epoxide reductase complex subunit 1, 16p11.2) is the main genetic determinant of human response to oral anticoagulants of antivitamin K type (AVK). This gene was recently suggested to be a putative target of positive selection in East Asian populations. In this study, we genotyped the HGDP-CEPH Panel for six VKORC1 SNPs and downloaded chromosome 16 genotypes from the HGDP-CEPH...

En los últimos años se ha incrementado el consumo de anticoagulantes orales debido a la alta incidencia enfermedades cardiovasculares y al desarrollo nuevos medicamentos. Estos fármacos están relacionados con un elevado índice problemas salud PRM/RNM.
 Se realizó estudio observacional transversal en una farmacia comunitaria urbana Valladolid para evaluar seguridad ACOD comparación AVK func...

BACKGROUND Central corneal thickness (CCT) is an important indicator of corneal status. Its measurement provides valid information about corneal physiological condition and possible changes associated with diseases, traumas, and hypoxia. It is an integral part for interpretation of intraocular pressure and glaucoma patient management and in prerefractive procedure assessment. OBJECTIVE The ai...

Este artigo analisou a produção científica sobre mulheres grávidas portadoras de Válvula Cardíaca Mecânica (VCM), que necessitam fazer o uso anticoagulação, considerando as melhores opções terapêuticas, baseado no risco do cada droga durante gestação. A gravidez gera um estado hipercoagulabilidade, atrelado ao material sintético da prótese cardíaca, aumenta chance formação trombo em relação às ...

Specification of neuron identity requires the activation of a number of discrete developmental programs. Among these is pathway selection by growth cones: in order for a neuron's growth cone to respond appropriately to guidance cues presented by other cells or the extracellular matrix, the neuron must express genes to mediate the response. The fax-1 gene of C. elegans is required for pathfindin...

Background: Canadian data on intracranial hemorrhage (ICH) associated with oral anticoagulation is limited. Objectives: Primary study outcomes were baseline hematoma volumes and in-hospital mortality in patients ICH direct anticoagulants (DOACs) versus vitamin K antagonists (VKAs). Second-ary included the use of four-factor prothrombin complex concentrate (4f-PCC). Methods: Retrospective cohort...

Although we usually would like to work with exact systems, most of the real world systems are nonlinear with uncertain parameters. In this paper, we propose AVK (A.V. Kamyad) approach to solve nonlinear problems with uncertain parameters (NPUP). This approach substitutes the original nonlinear system with an equivalent nonlinear programming (NLP) problem. Using this approach, we found an optima...