MAX NEUENDORF,1 AES Member, MARKUS MULTRUS,1 AES Member, NIKOLAUS RETTELBACH1, GUILLAUME FUCHS1, JULIEN ROBILLIARD1, JÉRÉMIE LECOMTE1, STEPHAN WILDE1, STEFAN BAYER,10 AES Member, SASCHA DISCH1, CHRISTIAN HELMRICH10, ROCH LEFEBVRE,2 AES Member, PHILIPPE GOURNAY2, BRUNO BESSETTE2, JIMMY LAPIERRE,2 AES Student Member, KRISTOFER KJÖRLING3, HEIKO PURNHAGEN,3 AES Member, LARS VILLEMOES,3 AES Associat...

BACKGROUND Determination of drug safety and tolerability is usually based on the frequency of certain key adverse events (AEs) rather than the frequency of all-grade toxicities. We assessed the reporting of key AEs in oncology randomized, controlled trials (RCTs) and compared that with the expectations of the European Organization for Research and Treatment of Cancer (EORTC) membership. MATER...

There are various methods to collect adverse events (AEs) in clinical trials. The methods how AEs are collected in vaccine trials is of special interest: solicited reporting can lead to over-reporting events that have little or no biological relationship to the vaccine. We assessed the rate of AEs listed in the package insert for the virosomal hepatitis A vaccine Epaxal(®), comparing data colle...

In this paper an efficient hardware architecture design and implementation of all candidates of AES encryption standards AES-128, AES-192 and AES-256 on the same hardware is proposed. AES algorithm proposed by NIST has been widely accepted as best cryptosystem for wireless communication security. The hardware implementation is useful in wireless security like military and mobile phones. This co...

OBJECTIVES Acetaminophen and nonsteroidal anti-inflammatory drugs (NSAIDs) are antipyretic analgesics with established adverse effects (AEs); however, only a few studies have compared their AEs simultaneously. We aimed to compare the AEs of these medications to confirm the respective frequencies of both rare and major AEs. METHODS We used a high-quality database for spontaneous adverse drug e...

BACKGROUND To investigate the average and extrapolated excess length of stay and direct costs of adverse events (AEs) and preventable AEs in Dutch hospitals, and to evaluate patient characteristics associated with excess length of stay and costs. METHODS Data of a large retrospective patient record review study on AEs was used. A stratified sample of 20 Dutch hospitals was included. Excess le...

Adverse events (AEs) occur in health care and may result in harm to patients especially in the field of surgery. Our objective was to analyze AEs in surgical patient care from a nationwide perspective and to analyze the frequency of AEs that may be preventable. In total 19,141 randomly selected admissions in 63 Swedish hospitals were reviewed each month during 2013 using a 2-stage record review...

AES is the best known and most widely used block cipher. Its three versions (AES128, AES-192, and AES-256) differ in their key sizes (128 bits, 192 bits and 256 bits) and in their number of rounds (10, 12, and 14, respectively). In the case of AES-128, there is no known attack which is faster than the 2 complexity of exhaustive search. However, AES-192 and AES-256 were recently shown to be brea...

S-box is a unique nonlinear operation in Rijndael, one encryption algorithm chosen as AES, and it determines the performance of AES. In this paper, the weaknesses in complexity and security of AES S-box are analyzed. We propose to increase the complexity and security of AES S-box by modifying the affine transformation and adding an affine transformation. Performance analysis demonstrates that t...