LTR retrotransposons are repetitive DNA elements comprising ∼10% of the human genome. However, LTR sequences are disproportionately present in human long, non-coding RNAs (lncRNAs). Whether and how the LTR lncRNAs serve biological functions are largely unknown. Here we show that in primary human erythroblasts, lncRNAs transcribed from the LTR retrotransposons of ERV-9 human endogenous retroviru...

We focused on transcription factors and epigenetic marks that regulate the B3GALT5 gene through its retroviral long terminal repeat (LTR) promoter. We compared the expression levels of the B3GALT5 LTR transcript, quantitated by competitive RT-PCR, with those of the candidate transcription factors HNF1α/β and Cdx1/2, determined by Western blot analysis, in colon cancer biopsies, various cell lin...

We sequenced the large terminal repeats (LTRs) present in infectious cloned DNA segments of leukemogenic, mink cell focusforming MCF13 and non-leukemogenic, MCF111A murine leukemia viruses (MuLVs; 1). We compare these sequences with LTRs of AKR ecotropic (AKR ECO; 2), NZB xenotropic (NZB XENO; 3) and MCF247 (4) MuLV DNAs. MCF111A LTR is used as the "standard." Dots show identity; blank space, a...

HIV-1 provirus, either as a chromosomal integrant or as an episomal plasmid in HeLa cells, forms a transcription-dependent gene loop structure between the 5'LTR promoter and 3'LTR poly(A) signal. Flavopiridol-mediated inhibition of RNA polymerase II elongation blocks 5' to 3'LTR juxtaposition, indicating that this structure is maintained during transcription. Analysis of mutant or hybrid HIV-1 ...

To examine the potential regulatory involvement of retroelements in the human genome, we screened the transcribed sequences of GenBank and expressed sequence tag data bases with long terminal repeat (LTR) elements derived from different human endogenous retroviruses. These screenings detected human transcripts containing LTRs belonging to the human endogenous retrovirus-E family fused to the ap...

Retrotransposons with long terminal repeats (LTR-RTs) are widespread mobile elements in eukaryotic genomes. We obtained a total of 81 partial LTR-RT sequences from lentil corresponding to internal retrotransposon components and LTRs. Sequences were obtained by PCR from genomic DNA. Approximately 37% of the LTR-RT internal sequences presented premature stop codons, pointing out that these elemen...

Previously, we characterized the transposition of an intracisternal type A particle (IAP) to the 3' untranslated region (UTR) of the interleukin-3 (IL-3) gene, which displaced two of the six AUUUA motifs associated with mRNA stability in an IL-3-secreting clone. To determine whether this rearrangement was involved in the autocrine transformation of the parental IL-3-dependent FL5.12 cell line, ...

Although replication-incompetent herpes simplex virus (HSV) vectors have the capability to express foreign genes, successful development of these vectors for gene delivery would require that expression of the foreign gene be regulated. To investigate the feasibility of obtaining inducible expression of a foreign gene in such a vector, a replication-incompetent HSV vector, vd120/LTR beta, was de...

Recently, computer vision foundation models such as CLIP and ALI-GN, have shown impressive generalization capabilities on various downstream tasks. But their abilities to deal with the long-tailed data still remain be proved. In this work, we present a novel framework based pre-trained visual-linguistic for recognition (LTR), termed VL-LTR, conduct empirical studies benefits of introducing text...

Abstract The LE is the low energy telescope that carried on Insight -HXMT. It uses swept charge devices (SCDs) to detect soft X-ray photons. LE’s time response caused by structure of SCDs. With theoretical analysis and Monte Carlo simulations we discuss influence (LTR) timing from three aspects: power spectral density, pulse profile lag. After LTR, value density monotonously decreases with incr...