Objectives: Digoxin is an antiarrhythmic drug with a narrow therapeutic range and used in clinical conditions such as heart failure atrial fibrillation. The planar frontal QRS-T angle reflects the deviations between depolarization repolarization of ventricles, it has been reported that increase this associated mortality. In our study, relationship digoxin use blood level was investigated. Metho...

This case report describes several electrocardiographic findings in an 8-years old female Pomeranian dog that was referred with a history of digoxin overdose. Electrocardiographic abnormalities detected in this case could be classified as primary electrocardiographic disturbances, reflecting cardiac chamber enlargement and secondary ECG changes, attributed to digoxin toxicity. ECG manifestatio...

Decreased cardiac responsiveness to adrenergic stimulation has been observed in cholestatic liver disease, but the cause remains unclear. Previous reports have suggested that nitric oxide overproduction might have a role in cholestasis-induced bradycardia via inhibition of L-type calcium channels. In the present study, the digoxin has been used to increase cardiac Ca2+ transient in male Sprague...

Toxicity from digitalis is a typical clinical issue. In this case, the interaction of digoxin and furosemide becoming more widely recognised as major cause toxicity. We present an abnormal ECG that demonstrates digoxin-induced cardiotoxicity. report case Digoxin toxicity in 79-year-old male patient admitted with complains nausea, increase frequency micturition, decrease appetite, nocturia, shor...

The purpose of this investigation was to evaluate the effect of digoxin on aerobic performance in mildly symptomatic patients with congestive heart failure and sinus rhythm. Ten patients (8 men and 2 women) with idiopathic dilated cardiomyopathy (ejection fraction 17 to 33%, mean 27 +/- 4%) who were stable and mildly symptomatic with maintenance digoxin and diuretic therapy were studied. All pa...

To investigate the basis for a clinically important digitalis-quinidine interaction that is characterized by increases in serums digoxin concentrations when quinidine is administered to digoxin-treated patients, we have studied in vitro the interaction of quinidine with the digoxin receptor. Evidence has been obtained that quinidine is capable of decreasing the affinity for digoxin of cardiac g...

Plasma myocardial, and skeletal muscle digoxin concentrations were measured in 32 patients undergoing cardiopulmonary bypass who were on long-term treatment with digoxin. The patients were divided into 4 groups according to the daily digoxin dose and the interval between discontinuation of the drug and operation. Before bypass, the mean digoxin concentrations were 1.58 nmol/l (1.24 ng/ml) in pl...

Digoxin was developed as a novel medication for the treatment of heart failure and atrial fibrillation (AF) 200 years ago. This investigation began with PubMed Google Scholar search various papers using terms digoxin safety efficacy, in failure, fibrillation. should be administered at dose 0.5–0.7 ng/mL individuals reduced ejection fraction. to decrease hospital readmissions, although SDC, crea...