This paper presents a comparison of several effective methods of deriving the critical feeding conditions for the case of a semi-batch catalytic reactor used for the acetoacetylation of pyrrole with diketene in homogeneous liquid phase. The reaction is known to be of high risk due to the very exothermic (polymerisation) side-reactions involving reactive diketene. In order to perform the sensiti...

The safe operation of a semi-batch catalytic reactor remains a sensitive issue when highly exothermic side reactions may occur, and various elements such as controllability, stability, safety, and economic aspects have to be considered in the process development. Nominal operating conditions are set to avoid excessive thermal sensitivity to variations in the process parameters. Several shortcut...

Reactions of unsaturated hydrocarbons with fluoroformyl cation (CFO+) and of ketene and diketene with CFO+ and CF3 have been studied in a Flowing Afterglow-Selected Ion Flow Tube (FA-SIFT) in helium at room temperature. Net F+ transfer from CFO+ to the neutral reactants, which is observed in the majority of cases studied, can be explained in terms of formation of a covalent adduct followed by e...