Although the brownish area at the corneal periphery in the region ofDescemet's membrane was first described by Kayser (I902), and Fleischer (I9I2) recognized it as a part of Wilson's disease (hepato-lenticular degeneration), there have been no previous reports in the ophthalmic literature of the United Kingdom of a pathological study of the lesion which is now recognized as a pathognomonic find...

In Schramm & Kayser (1995) we introduced the complex Beltrami Equation as an appropriate framework for the analysis of arclets in cluster lensing. Corresponding real formalisms have been developed by Kaiser and Schneider & Seitz (this volume, compare also the references in Schramm & Kayser 1995). Here, we show how the solutions of the Beltrami differential equation can be used to identify multi...

PURPOSE To present anterior segment optical coherence tomography (AS-OCT) findings of the Kayser-Fleischer (KF) ring in Wilson disease (WD) and to discuss the potential advantages of evaluating the KF ring by AS-OCT. METHODS This is a retrospective case series of 7 patients with WD with KF rings seen in our institute during the study period (August 2015 to June 2016). All patients underwent s...

Wilson's disease (WD) is a rare autosomal recessive inborn error of copper metabolism caused by a mutation to the copper-transporting gene ATP7B. The presentation is usually neurologic or hepatic, seen in 40% of patients. Diagnosis depends primarily on clinical features, biochemical parameters and the presence of the Kayser-Fleischer ring. Here a case of Wilson disease with various neurological...

Wilson disease is an autosomal recessive copper storage disease resulting from an inability of the liver to excrete copper. Patients can present at a young age, generally with symptoms of liver copper intoxication, or later on, generally with neurological symptoms. The gene for Wilson disease has recently been cloned. Five mutations have been described so far, but only one is found frequently, ...