Purified preparations of normal C1(-)-inhibitor (C1(-)-INH) formed high mol wt complexes with plasma kallikrein that were stable during sodium dodecyl sulfate (SDS)-gel electrophoresis, but most of the dysfunctional C1(-)-INH proteins isolated from plasma of patients with type II hereditary angioneurotic edema (HANE) did not. Two of eight dysfunctional C1(-)-INH proteins were cleaved to lower m...

Several types of angioedema exist beyond hereditary angioedema (HAE) types I/II; however, the diagnostic and treatment needs of these conditions are not well understood. Noticeably, there are no licensed treatments available for other forms of angioedema beyond HAE types I/II, and similarly they are unresponsive to conventional antihistamine/glucocorticoid treatment. A group of angioedema exper...

T he treatment of combination atlas-axis fractures based primarily on the specific characteristics of the axis fracture is recommended. • External immobilization of most C1-C2 combination fractures is recommended. • C1-type II odontoid combination fractures with an atlanto-dental ratio of $ 5 mm and C1-Hangman combination fractures with C2C3 angulation of $ 11 should be considered for surgical ...

In adult mice we determined whether expression of angiotensin II (Ang II) type 1A receptors (AT(1A)Rs) in C1 neurons mediates the excitation of the rostral ventrolateral medulla (RVLM) by Ang II. Blood pressure, heart rate, and sympathetic nerve activity were measured in anesthetized, artificially ventilated wild-type (n=15) and AT(1A)R knockout (AT(1A)(-/-); n=9) mice. Microinjection of Ang II...

In adult mice we determined whether expression of angiotensin II (Ang II) type 1A receptors (AT1ARs) in C1 neurons mediates the excitation of the rostral ventrolateral medulla (RVLM) by Ang II. Blood pressure, heart rate, and sympathetic nerve activity were measured in anesthetized, artificially ventilated wild-type (n 15) and AT1AR knockout (AT1A / ; n 9) mice. Microinjection of Ang II (50 nL ...

Thromb Haemost 2006; 95: 898–9 Deficiency of the C1-inhibitor (C1-INH) is a very rare cause of angioedema. A hereditary (1) and an acquired form (2, 3) of C1-INH deficiency have been described. Two types of acquired angioedema (AAE) exist: type I is associated with lymphoproliferative disorders, whereas type II is characterized by autoantibodies against C1-INH (4). Clinically, AAE is indistingu...

An 18-year-old male presented after a motor vehicle rollover accident. Computed tomography (CT) scan confirmed the diagnosis of Type II odontoid fracture. Considering the patient's young age and the limitations of C1-C2 fusion including significant loss of cervical rotation, temporary internal fixation with a lateral mass fixation of C1 and pedicle fixation of C2 without fusion was done. CT sca...

The performance of an 8-noded hexahedron C1* element in elasticity is investigated. Three translational displacements and their derivatives as strain in each direction are considered as degrees of freedom (d.o.f.’s) at each node. The geometric mapping is enforced using a C0 element with no derivative as nodal d.o.f.’s . The stiffness matrix of the element is also computed using a transformation...