The bioactive component harpagoside was successfully separated from the crude extract of Scrophularia ningpoensis Hemsley by one-step purification using high-speed counter-current chromatography (HSCCC). A two-phase solvent system containing n-butanol:ethyl acetate:water (1:9:10) was selected following consideration of the partition coefficient of the target compound. A 276 mg quantity of the c...

Article Type Research Article Authors Soufiabadi M.* PhD

AIM To investigate the antioxidative activity of the constituents of the roots of Scrophularia ningpoensis (Chinese name: Xuanshen). METHODS The main compounds from the roots of Scrophularia ningpoensis were isolated and identified by chromatography and FABMS, NMR etc. Using the techniques of pulse radiolysis, the electron transfers from iridoid glycosides (IG) or phenylpropanoid glycosides (...

Background: Numerous plants in traditional practices of medicine have been used to treat cognitive disorders, including neurodegenerative diseases such as Alzheimer’s disease (AD) and other memory related disorders. Materials and Methods: We present here the evaluation of acetylcholinesterase (AChE) inhibitory and antioxidant activities of the aqueous methanol extracts of five traditional medic...

Article Type Research Article Authors Soufiabadi M.* PhD

Breast cancer is a prevalent malignancy among women, especially in developing countries. A large number of anticancer agents with herbal origins have been reported. Hence, herbals may play an essential role in prevention and treatment of cancers. We investigated cytotoxic effects of dichloromethane fractions of Scrophularia oxysepala extract on the MCF-7 breast cancer cell line. The cytotoxic a...

We have previously shown that scropolioside B has higher anti-inflammatory activity than catalpol does after the inhibition of nuclear factor (NF)-κB activity and IL-1β expression, maturation, and secretion. Various scropoliosides were extracted, isolated, and purified from Scrophularia dentata Royle ex Benth. We then compared their anti-inflammatory activities against LPS-induced NF-κB activit...

در پژوهش حاضر، فراوانی و شاخص‌های تنوع گونه‌ای مگس‌های خانواده Tachinidae هفت منطقه از استان مازندران سال 1390، بر اساس نمونه‌برداری‌های مستمر منظم با استفاده تله مالیز ارزیابی شد. مجموع تعداد 280 نمونه 48 گونه، 38 جنس‌ چهار زیرخانواده این استان‌ جمع‌آوری شناسایی شدند. گونه‌های زیرخانوادهTachininae بیشترین را مناطق مورد مطالعه داشته پس آن Phasiinae قرار دارد. زیرخانواده‌های Exoristinae 16 گونه ...