Introduction: leiomyoma is the most common benign esophageal neoplasm. Surgical treatment (enucleation) has traditionally been the therapy of choice. The advent of minimally invasive techniques has produced an increase in endoscopic approaches to the detriment of open surgery. Objective: the aim of this study was to compare the results obtained with open surgery and with laparoscopic surgery in...

We present a new model independent amplitude analysis of reaction πp → π−π+n measured at CERN at 17.2 GeV/c on polarized target using a Monte Carlo method in an extended range of dipion mass 580–1080 MeV. The two solutions for the measured moduli |S|2Σ and |S|2Σ of the two S-wave transversity amplitudes S and S show resonant behaviour below 800 MeV corresponding to a scalar resonance σ(770). Si...

Vx-770 (Ivacaftor), a Food and Drug Administration (FDA)-approved drug for clinical application to patients with cystic fibrosis (CF), shifts the paradigm from conventional symptomatic treatments to therapeutics directly tackling the root of the disease: functional defects of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel caused by pathogenic mutations. The unde...

From the ‡Institute for Health Sciences, Tokushima Bunri University, 180 Nishihama-bouji, Yamashiro-cho, Tokushima 770-8514, Japan, the **Department of Biological Sciences and Technology, Faculty of Engineering, the University of Tokushima, 2-1 Minamijosanjimacho, Tokushima 770-8506, Japan, the ‡‡Structural Biophysics Laboratory, RIKEN Harima Institute at SPring-8, 1-1-1 Kouto, Mikazuki, Sayo, ...

BACKGROUND P. aeruginosa is an opportunistic pathogen that chronically infects the lungs of 85% of adult patients with Cystic Fibrosis (CF). Previously, we demonstrated that P. aeruginosa reduced wt-CFTR Cl secretion by airway epithelial cells. Recently, a new investigational drug VX-809 has been shown to increase F508del-CFTR Cl secretion in human bronchial epithelial (HBE) cells, and, in comb...

BACKGROUND A new approach in the treatment of cystic fibrosis involves improving the function of mutant cystic fibrosis transmembrane conductance regulator (CFTR). VX-770, a CFTR potentiator, has been shown to increase the activity of wild-type and defective cell-surface CFTR in vitro. METHODS We randomly assigned 39 adults with cystic fibrosis and at least one G551D-CFTR allele to receive or...

Department of Preventive Environment and Nutrition, Institute of Health Biosciences, 3-18-15, Kuramoto-cho, Tokushima city, Tokushima 770-8503, Japan Department of Electrical and Electronic Engineering, Institute of Socio Techno Sciences, 2-1, Miname Jyosanjima-cho, Tokushima city, 770-8506, Japan The University of Tokushima Graduate School Corresponding author: Akira Takahashi, M.D., Ph.D., De...

Los bienes con elementos digitales sirven de hilo conductor para detectar las diferencias entre la Directiva (UE) 2019/770 y 2019/771. Las una otra norma sugieren si es posible integrar el régimen los (Directiva 2019/770) reglas contenidas en sobre compraventa.

CERN measurements of πp → ππn on polarized target at 17.2 GeV/c enable experimental determination of partial wave production amplitudes below 1080 MeV. The measured S-wave transversity amplitudes provide evidence for a narrow scalar resonance σ(770). The assumption of analyticity of production amplitudes in dipion mass allows to determine S-wave helicity amplitudes S0 and S1. The helicity flip ...