background: fecal microbiota transplant (fmt) is employed to replace the ‘unhealthy’ microbiota of the patient with the ‘healthy’ microbiota of a pre-screened healthy donor. given the growing importance of gut microbiota dysbiosis in the pathogenesis of intestinal or extraintestinal diseases; it is conceivable that fmt becomes integrated in the routine clinical practice. our objective was to as...

Clostridium difficile causes antibiotic-associated diarrhea and pseudomembraneous colitis and is responsible for a large and increasing fraction of hospital-acquired infections. Fecal microbiota transplantation (FMT) is an alternate treatment option for recurrent C. difficile infection (RCDI) refractory to antibiotic therapy. It has recently been discussed favorably in the clinical and scientif...

Background/Aims Chronic intestinal pseudo-obstruction (CIPO) is a serious, life-threatening motility disorder that is often related to bacterial overgrowth. Fecal microbiota transplantation (FMT) results in restoration of the normal intestinal microbial community structure. We investigated the efficacy of FMT in the treatment of CIPO patients. Methods Nine patients (age 18-53 years) with CIPO...

BACKGROUND Fecal microbiota transplantation (FMT) is reportedly the most effective therapy for relapsing Clostridium Difficile infection (CDI) and a potential therapeutic option for many diseases. It also poses important ethical concerns. This study is an attempt to assess clinicians' perception and attitudes towards ethical and social challenges raised by fecal microbiota transplantation. ME...

Few studies have been conducted on the attitudes of patients seeking fecal microbiota transplantation (FMT). This study aimed to investigate the reasons for patients with Crohn's disease (CD) seeking FMT and their attitude changes after FMT.In this prospective study, all included patients were diagnosed with CD for at least 6 months and intended to receive FMT. A questionnaire was designed to i...

Having recently established a faecal microbiota transplantation (FMT) programme, we raise two points about Spector and Knight’s editorial on FMT. Firstly, despite the UK’s relatively permissive regulatory framework on FMT, we encountered considerable obstacles to establishing an NHS programme. Donor screening is expensive (>£500 (€703; $755)/screen/donor, repeated regularly). It is unclear whet...

BACKGROUND Studies of colonoscopic fecal microbiota transplant (FMT) in patients with recurrent CDI, indicate that this is a very effective treatment for preventing further relapses. In order to provide this service at Stony Brook University Hospital, we initiated an open-label prospective study of single colonoscopic FMT among patients with ≥ 2 recurrences of CDI, with the intention of monitor...

IMPORTANCE Clostridium difficile infection (CDI) is a major burden in health care and community settings. CDI recurrence is of particular concern because of limited treatment options and associated clinical and infection control issues. Fecal microbiota transplantation (FMT) is a promising, but not readily available, intervention. OBJECTIVE To determine whether frozen-and-thawed (frozen, expe...

To the Editor: We read with interest the article by Suskind et al evaluating the safety and potential efficacy of fecal microbial transplant (FMT) in patients with Crohn’s disease (CD). The author found that FMT for CD may be a possible therapeutic option for CD. Because their findings are important to current therapy for CD, several questions deserve further attention. FMT has come to the fore...