Fixed Drug Eruption (FDE) is classified as cutaneous drug reaction which recurs in the same locations upon systemic administration of the same drug. Vesicles and bullae may sometimes be found, and in some cases even these are confused with Stevens Johnson Syndrome (SJS) or Toxic Epidermal Necrolysis (TEN). A male patient, 62 years old, developed FDE with the use of ornidazole. On physical exami...

To improve the stability of optochemical sensors (optodes), the fluorescence indicator 1-amino-4-allyloxyanthraquinone (AAA), which was synthesized by reacting allyl bromide with 1-amino-4-hydroxyanthraquinone, was covalently immobilized on surface-modified glass slides. The resulting sensor was used to determine the content of ornidazole based on fluorescence quenching. It showed a linear resp...

The present study investigated safety/toxicity profile of fixed dose combination of Ofloxacin-Ornidazole injection in Mus musculus mice at three dose levels, ranging from asymptomatic to high dose. To enhance the antimicrobial spectrum of the quinolones against anaerobic organisms and gram positive bacteria, fixed dose combination of Ofloxacin and Ornidazole injection was introduced. It has bee...

A comparison is made between oral ornidazole in a single 1-5 g dose and tinidazole given in a 2 g dose using a double-blind technique. All the 45 women with Trichomonas vaginalis infection who were treated with ornidazole were cured. In the tinidazole-treated group 41 out of 43 women had negative cultures after treatment. Tolerance was good in both groups.

Various techniques are employed to enhance the aqueous solubility of poorly watersoluble drugs and hydrotropic solubilization is one of them. In the present investigation, hydrotropic solution of ibuprofen sodium (0.5M) was employed as solubilizing agent to solubilize the poorly water-soluble drug, ornidazole from fine power of its tablets for spectrophotometric determination. Ornidazole shows ...

In this study, we determined the in vitro inhibitory effects of ceftriaxone sodium, imipenem and ornidazole on hydratase and esterase activities of human erythrocyte carbonic anhydrase-I and II isozymes (CA I and II). Human erythrocyte CAI and II isozymes were purified by Sepharose-4B L-tyrosine affinity chromatography column with a yield of 30% and 40%, a specific activity of 920 and 8,000 EU/...

OBJECTIVE Treatment of Demodex infestations is often inadequate and associated with low effective rate. We sought to evaluate the efficacy of an ornidazole-based sequential therapy for mites folliculitis treatment. METHODS Two-hundred patients with mites folliculitis were sequentially treated with either an ornidazole- or metronidazole-based regimen. Sebum cutaneum was extruded from the sebac...

Case report A 40-year old woman applied to the Immunology and Allergy clinic with pruritic erythematous lesions over the lateral sides of both arms and right hip within 30 minutes after the ingestion of ornizadole 500 mg tablet. She reported that five recurrent reactions emerged with the same drug on the same locations previously, and their severity was increased consecutively. She was prescrib...

The nitroimidazole group of antibiotics like metronidazole have been reported to cause cerebellar ataxia as a rare side effect. Ornidazole, the newest derivative of this class, has a long half life and is very rarely known to cause cerebellar ataxia. Here, we report a 61-year-old patient who developed ataxia due to ornidazole to highlight an unusual adverse event that improved rapidly after dis...

The genotoxicity study of ornidazole (ONZ) was carried out on human lymphocyte chromosomes, using sister chromatid exchange (SCE) and micronucleus (MN). Thirty-two patients with Entemoeba histolitica infection who received 1000 mg/day for 10 days were included in this study. SCE and MN were measured before and after therapy. A statistically significant increase was observed in the SCE (P < 0.00...