Introduction Reduction of ultra high molecular weight polyethylene (UHMWPE) surface wear in total knee replacement (TKR) bearings may delay the onset of osteolysis and subsequent loosening of components. Crosslinking has been shown to increase the wear resistance of UHMWPE bearings in multidirectional total hip replacement applications when articulating against smooth counterfaces [1]. The aim ...

Graphene oxide (GO)/ultrahigh-molecular-weight polyethylene (UHMWPE) composites were successfully fabricated through the mechanical ball milling technology and processed according to the hot pressing method. The fractured microstructure features and mechanical properties of the GO/UHMWPE composites were investigated by Scanning electron microscope (SEM) and universal testing machine, respective...

Despite advances in orthopedic materials, the development of drug-eluting bone and joint implants that can sustain the delivery of the drug and maintain the necessary mechanical strength in order to withstand loading has remained elusive. Here, we demonstrate that modifying the eccentricity of drug clusters and the percolation threshold in ultrahigh molecular weight polyethylene (UHMWPE) result...

Dendritic cells (DCs) were shown to enhance UHMWPE particle promoted osteoclastogenesis in RAW264.7 macrophages. This study aimed to elucidate the signaling network mediating the osteoclastogenic effects of UHMWPE particles and DCs. RAW264.7 cells were induced with UHMWPE particles and /or DC2.4 cells. The expression of Rank was silenced by shRNA. The activation of p38MAPK, AKT, and NF-κB was i...

Macrophages constitute a major part of the cell response to wear particles produced at articulating and nonarticulating interfaces of joint replacements. This foreign body reaction can result in periprosthetic osteolysis and implant loosening. We demonstrate that ultra-high molecular weight polyethylene (UHMWPE) particles induce systemic trafficking of macrophages by noninvasive in vivo imaging...

Fluorinated graphene/ultra high molecular weight polyethylene (FG/UHMWPE) composites were prepared by ultrasonic dispersion and hot pressing. The mechanical propertys and tribological property of pure UHMWPE and FG/UHMWPE composites were investigated by micro hardness tester and high-speed reciprocating friction tester. The wear volume of the sample was measured by the scanning electron microsc...

Ultra high molecular weight polyethylene (UHMWPE) has been used as a load bearing and articulating counter face in total knee replacement (TKR) for over forty years1. However, wear debris generation of UHMWPE materials after their implantation in the human body has been proven to induce osteolysis and aseptic loosening, which is the main cause of long-term failure of TKR composed of UHMWPE and ...

Ultra-high molecular weight polyethylene (UHMWPE) has been the most commonly used bearing material in total joint arthroplasty. Wear and oxidation fatigue resistance of UHMWPE are regarded as two important properties to extend the longevity of knee prostheses. The present study investigated the accelerated ageing of UHMWPE in hydrogen peroxide highly oxidative chemical environment. The sliced s...