BACKGROUND & AIMS Nutrients and properties of lipases affect survival of lipolytic activity during aboral gastrointestinal transit. Whether different doses and formulations of bacterial lipase and diets affect steatorrhea was tested in pancreatic-insufficient dogs. METHODS A dose of 0-600,000 IU of powdered and 135,000 and 300,000 IU of liquid bacterial lipase was given with a standard meal t...

This CIBA Symposium on the intestinal mucosa represents a timely review of dissecting, light, and electron microscopic studies of the small bowel. Booth, et al. describes dissecting microscopic changes in the small bowel, some of which could not be appreciated by the light microscope. The dissecting microscope appears to be widely employed by the British and Europeans, but neglected by the Amer...

This CIBA Symposium on the intestinal mucosa represents a timely review of dissecting, light, and electron microscopic studies of the small bowel. Booth, et al. describes dissecting microscopic changes in the small bowel, some of which could not be appreciated by the light microscope. The dissecting microscope appears to be widely employed by the British and Europeans, but neglected by the Amer...

BACKGROUND Primary hyperparathyroidism is a rare cause of chronic pancreatitis and there is a paucity of data on this interesting association. There is also no data comparing the clinical profile of chronic pancreatitis secondary to primary hyperparathyroidism with that of alcohol related and idiopathic chronic pancreatitis. METHODS The clinical and biochemical spectrum of chronic pancreatiti...

BACKGROUND Fecal elastase-1(FE-1) has been suggested as an alternative to steatorrhea quantification to evaluate pancreatic insufficiency, but its diagnostic performance has not been compared with steatorrhea in chronic pancreatitis or after pancreatic resection. METHODS The relationship between steatorrhea and FE-1 was studied in patients with chronic pancreatic disorders or pancreatic resec...

This study aimed to investigate the occurrence of and determine the risk factors for steatorrhea in chronic pancreatitis (CP). It was based on analysis of both retrospectively and prospectively acquired database for CP patients admitted to our center from January 2000 to December 2013. Demographic data, course of disease, medical history, and follow-up evaluations of patients were documented in...

Although it is well documented that blind loop of the small intestine, either spontaneously occurring (2) or experimentally produced (3-5), is associated with steatorrhea, the mechanism for this abnormality has not been demonstrated. A pathogenic role of bacteria is strongly suggested in this and closely associated conditions by the observations that bacterial overgrowth of the small bowel occu...

High-fat diets are often associated with greater caloric intake and weight gain. Since satiety during fat intake is induced by fat in the intestine we investigated the efficiency of a lipid compound that retards fat digestion to regulate fat intake. We found this compound to reduce high-fat food intake, body weight and blood lipids in Sprague-Dawley rats, without causing steatorrhea. The absenc...