OBJECTIVES To characterize the efficacy and tolerability of multiple drug therapy (MDT) among heavily pre-treated HIV-infected children. METHODS An observational study of seven children treated with 4-7 antiretroviral agents. MDT regimens were chosen with regard to past antiretroviral exposure and genotypic resistance data. Five children received MDT once, one child twice and one child four t...

Maggot debridement is the deliberate use of larvae known to consume only necrotic tissue. A retrospective quality improvement analysis of maggot debridement therapy (MDT) was conducted among patients with devitalized tissue or gangrene attending a Canadian foot and leg ulcer clinic who received MDT between January 2001 and June 2006. MDT was applied every 48 hours until >90% of necrotic tissue ...

[1] Mean Dynamic Ocean Topography (MDT) is the difference between the timeaveraged sea surface height and the geoid. Combining sea level and geoid measurements, which are both attained primarily by satellite, is complicated by ocean variability and differences in resolved spatial scales. Accurate knowledge of the MDT is particularly difficult in the Southern Ocean as this region is characterize...

Purpose Cervical cancer is a major cause of mortality in low- and middle-income countries (LMICs) and the most common cancer diagnosed in women in Botswana. Most women present with locally advanced disease, requiring chemotherapy and radiation. Care co-ordination requires input from a multidisciplinary team (MDT) to deliver appropriate, timely treatment. However, there are limited published exa...

Let P be a simple planar polygon with n vertices. We would like to find a triangulation MDT(P) of P that minimizes the diameter of the dual tree. We show that MDT(P) can be constructed in O(n log n) time. If P is convex, we show that the dual of any MDT has diameter 2 · dlog2(n/3)e or 2 · dlog2(n/3)e−1, depending on the value of n. We also investigate the relation between MDT(P) and the number ...

BACKGROUND More women with an increased risk of poor pregnancy outcome due to pre-existing medical conditions are becoming pregnant. Although clinical care provided through multi-disciplinary team (MDT) working is recommended, little is known about the structure or working practices of different MDT models, their impact on maternal and infant outcomes or healthcare resources. The objectives of ...

Knowledge of the ocean dynamic topography, defined as the height of the sea surface above its rest-state (the geoid), would allow oceanographers to study the absolute circulation of the ocean and determine the associated geostrophic surface currents that help to regulate the Earth's climate. Here a novel approach to computing a mean dynamic topography (MDT), together with an error field, is pre...

Reactive oxygen species (ROS) play important signaling roles in metazoans, but also cause significant molecular damage. Animals tightly control ROS levels using sophisticated defense mechanisms, yet the transcriptional pathways that induce ROS defense remain incompletely understood. In the nematode Caenorhabditis elegans, the transcription factor SKN-1 is considered a master regulator for detox...

The literature describing the effectiveness of multidisciplinary team (MDT) for the care of colorectal cancer remains unclear. We investigated the effects of MDT care on the quality of colorectal cancer treatment, and the emergency department visit number was used as an indicator. In total, 45,418 patients newly diagnosed with colorectal cancer from the Taiwan National Health Insurance Research...

PURPOSE This assesses the current workings of multidisciplinary team (MDT) meetings across Korea through surgeons' reports and their current commitments to MDT meetings pertaining to breast cancer, and to determine any perceived areas of potential improvement. METHODS A questionnaire was sent out to 307 members of The Korean Breast Cancer Society (KBCS) who worked at comprehensive or universi...