nal tissues, and their contributions to signaling during pulmonary development; however, are unknown. a5 was assessed by immunohistochemistry in mouse lungs from embryonic day (E) 13.5 to post-natal day (PN) 10. Transcriptional control of a5 was determined by transfection of murine pulmonary epithelial cell lines with reporter constructs containing 2.0 kb, 850 bp, or 450 bp of the mouse a5 prom...

nal tissues, and their contributions to signaling during pulmonary development; however, are unknown. a5 was assessed by immunohistochemistry in mouse lungs from embryonic day (E) 13.5 to post-natal day (PN) 10. Transcriptional control of a5 was determined by transfection of murine pulmonary epithelial cell lines with reporter constructs containing 2.0 kb, 850 bp, or 450 bp of the mouse a5 prom...

nal tissues, and their contributions to signaling during pulmonary development; however, are unknown. a5 was assessed by immunohistochemistry in mouse lungs from embryonic day (E) 13.5 to post-natal day (PN) 10. Transcriptional control of a5 was determined by transfection of murine pulmonary epithelial cell lines with reporter constructs containing 2.0 kb, 850 bp, or 450 bp of the mouse a5 prom...

OBJECTIVE Annexin A5 is a phosphatidylserine binding protein that binds dying cells in vivo. Annexin A5 is a potential molecular imaging agent to determine efficacy of anti-cancer therapy in patients. Its rapid clearance from circulation limits tumor uptake and, hence, its sensitivity. The aim of this study is to determine if non-invasive imaging of cell death in tumors will benefit from increa...

(99m)Tc-HYNIC-annexin A5 can be considered as a benchmark in the field of apoptosis imaging. However, (99m)Tc-HYNIC-annexin A5 has characteristics of high uptake and long retention in non-target tissues such as kidney and liver. To minimize this problem, we developed a novel (99m)Tc-labeled annexin A5 using a bis(hydroxamamide) derivative [C3(BHam)2] as a bifunctional chelating agent, and evalu...

A novel annexin A5 derivative (cys-annexin A5) with a single cysteine residue at its C-terminal has been developed and successfully labeled in high labeling yield with (99m)Tc by a ligand exchange reaction. Like the 1st generation (99m)Tc-HYNIC-annexin A5, the novel (99m)Tc-cys-annexin A5 derivative shows in normal mice mainly renal and, to a lesser extent, hepatobiliary excretion. In rat model...

Proteins of the annexin family bind to phospholipids in a Ca(2+) dependent manner. The exposure of phosphatidylserine (PS) by apoptotic as well as necrotic cells is one major eat-me-signal for macrophages. Annexin A5 (Anx A5) preferentially binds to PS. The availability of Anx A5 knock out (KO) mice allowed us to investigate for the first time if endogenous Anx A5 modulates the immune response ...

Objective:  Patient satisfaction is one of the most important indicators for measuring the quality of emergency services and health care. The purpose of this study was to evaluate the patients’ satisfaction in the emergency department (ED)...