نتایج جستجو برای: آنالیز in silico
تعداد نتایج: 17016896 فیلتر نتایج به سال:
background: neisseria meningitidis, a life-threatening human pathogen with the potential to cause large epidemics, can be isolated from the nasopharynx of 5–15% of adults. the aim of the current study was to evaluate biophysical and biochemical properties and immunological aspects of chimeric acyl-carrier protein-macrophage infectivity potentiator protein-type iv pilus biogenesis protein antige...
materials and methods in silico analysis of the cadf gene was carried out by several software and available online tools. a duplex pcr optimized with specific primers was used for detection and differentiation of both species. to evaluate specificity and sensitivity of the test, a panel of different campylobacter spp. together with several intestinal bacterial pathogens was tested. the limit of...
MOTIVATION We developed a technique and a tool for degenerate primer design based on multiple local alignments employing the MEME algorithm supported with electronic PCR. The objective is to find adequate primers starting from sequences with poor global similarity. We show an example of its application in our laboratory to find sequences in Brachiaria with similarity to ESTs related to apomixis.
2. Objectives ........................................................................................................... 4 2.a. Engineering a new Industry...................................................................................... 4 2.b. Mark the territory: the stakeholders .......................................................................... 5 2.c. Identify the 'issues' ..........
it has been suggested that single nucleotide polymorphisms (snps) in genes involved in toll-like receptors (tlrs) pathway may exhibit broad effects on function of this network and might contribute to a range of human diseases. however, the extent to which these variations affect tlr signaling is not well understood. in this study, we adopted a bioinformatics approach to predict the consequences...
human cytomegalovirus is one of the most common pathogenic viruses all over the world. in congenital infection leads to neurologic severe disorders and even death of fetus and in individuals with immunosuppression may also cause severe clinical symptoms. multiple evidence indicate that among several strategies, epitope-based vaccine (evs) that can induce both humoral and cellular immunity respo...
the properties relevant to pharmacokinetics and pharmacodynamics of four series of synthesized s-triazine derivatives have been studied by quantitative structure-retention relationship (qsrr) approach. the chromatographic behavior of these compounds was investigated by using reversed-phase high performance thin-layer chromatography (rp-hptlc). chromatographic retention (rm0) was correlated with...
غربالگری مجازی بر اساس ساختار و لیگاند و مطالعه کیوسار سه بعدی برای شناسایی آگونیست های جدید gpr 119
گیرنده جفت شده پروتئین g 119 (gpr 119) یک هدف جالب و امیدوارکننده برای درمان بیماری دیابت نوع 2 (t2dm) است. در این تحقیق، روابط کمّی ساختار- فعالیت سه بعدی، الحاق کردن مولکولی و غربالگری مجازی بر روی یک سری از آگونیست های جدید gpr 119 انجام شد. نتایج، توانایی پیش بینی و قابلیت اطمینان بالایی از مدل ها را نشان داد. یک مدل فارماکوفوری کیفی با استفاده از الگوریتم hip-hop ساخته شد. این مدل رضایت بخش...
چکیده تمام نما: در حال حاضر یکی از علل اصلی مرگ و میر در جهان بیماری سل می باشد. در حدود یک سوم جمعیت جهان آلوده به عامل این بیماری (mycobacterium tuberculosois ) هستند. تا کنون تلاش های بسیاری در زمینه درمان این بیماری صورت گرفته است، اما هنوز سل به عنوان یک مشکل باقی مانده است. در سالهای اخیر، پپتیدهای ضد میکروبی به عنوان عوامل درمانی امید بخش مورد توجه قرار گرفته اند. این بررسی با هدف شنا...
clostridium botulinum type a (bont/a) produces a neurotoxin recently found to be useful as an injectable drug for the treatment of abnormal muscle contractions. the catalytic domain of this toxin which is responsible for the main toxin activity is a zinc metalloprotease that inhibits the release of neurotransmitter mediators in neuromuscular junctions. a cell penetrating cationic peptide, tat, ...
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