objective: rna interference (rnai) is the most potent technique for gene silencing in eukaryotic cellular system at transcriptomic level. genetic disorders and cancers are important targets for therapeutic development of this technique. in order to bypass the temporary dpwnregulation by sirna, a new generation of shrna named shrnamir has developed. silencing construct with structure similar to ...

background: rna plays key role in many aspects of biological processes and its tertiary structure is critical for its biological function. rna secondary structure represents various significant portions of rna tertiary structure. since the biological function of rna is concluded indirectly from its primary structure, it would be important to analyze the relations between the rna sequences and t...

conclusions this information provides an explanation for the previously valuable literature on the functions of lncrnas and suggest for the novel therapeutic targeting. results the lncrnas hottip, h19, hotair, malat1, antisense igf2r (air), hoxa13, gtl2 (also called meg3) and uc002mb have been reported in association with hcc. besides, this study predicted that eif4aiii, ptb and fus were the mo...

ساختارهای شناختی ابعاد مهمی از ارزیابی­ها در روابط هستند. طرفی ایران خانواده­های همسران، نقش کیفیت زناشویی دارند. تحقیق حاضر به مطالعه بخشی این شناخت­ها یعنی استانداردها منظر والدین ایرانی درباره عروس و داماد مطلوب، با رویکرد پدیدارشناسی تفسیری، پرداخته است. بدین منظور 20 نفر دارای حداقل یک یا داماد، مصاحبه نیمه­ساختار یافته صورت گرفت. میانگین سنی مادران پدران ترتیب 5/57 5/58 سال بود. داده­ها ا...

Background: RNA interference (RNAi) is a phenomenon uses double-stranded RNA (dsRNA) to specifically inhibit gene expression. The non-specific silencing caused by interferon response to dsRNA in mammalian cells limits the potential of utilizing RNAi to study gene function. Duplexes of 21-nucleotide short interfering dsRNA (siRNA) inhibit gene expression by RNAi. In some organisms, siRNA can als...