BACKGROUND In vitro evidence suggests anti-estrogenic properties for retinol and carotenoids, supporting a chemo-preventive role of these phytochemicals in estrogen-dependent cancers. During aging there are significant reductions in retinol and carotenoid concentrations, whereas estradiol levels decline during menopause and progressively increase from the age of 65. We aimed to investigate the ...

Isoflavones are phytoestrogens which have estrogen-like activity in animals and humans with structure similar to 17-β-estradiol and capable of binding to estrogen receptors (ERs).This experiment was conducted to demonstrate the effect of isoflavones on estradiol concentration in blood and its influence on the productive performances in ISA Brown laying hens fed with supplemented feed with large...

Introduction:This study examined the effects of administration of subcutaneous β-estradiol on PTSD-like symptoms (the enhanced conditioned fear response, CFR) that induced by a single-prolonged stress (SPS) and shock in rats. Adult male Wistar rats were exposed to SPS procedure: restraint for 2 h, forced swim for 20 min, and ether anesthesia. Then the rats were placed in fear conditioning syste...

Background: The aim of this prospective randomized clinical trial was to determine the optimal endometrial preparation protocol by comparing the clinical outcome of two methods of endometrial preparation in FET cycles, that is, oral estradiol and 17 β-estradiol transdermal patch. Materials and Methods: A total number of 90 patients were scheduled for FET. In the study group (n=45), 17-B estradi...

introduction:this study examined the effects of administration of subcutaneous β-estradiol on ptsd-like symptoms (the enhanced conditioned fear response, cfr) that induced by a single-prolonged stress (sps) and shock in rats. adult male wistar rats were exposed to sps procedure: restraint for 2 h, forced swim for 20 min, and ether anesthesia. then the rats were placed in fear conditioning syste...

Background: The presence of estrogen receptor beta and aromatase in the germ cell has highlighted the physiological role of the traditionally female hormone, estrogen, in spermatogenesis. Estrogen receptor alpha knockouts and aromatase knockouts have further accentuated the role of estrogen in germ cell maturation. To delineate effects of high intratesticular estradiol in the seminiferous epith...

Background: The surgical management of liver injuries remains a great challenge for the traumatologists and general surgeons. We hypothesized that administration of 17 β-estradiol, a female sex hormone, improves hepatocellular healing after liver trauma. Methods: In an experimental model, 60 rats were divided into six subgroups: A (male control), B (male and estradiol), C (castrated male and es...

Estrogens have profound actions on the structure of the nervous system during development and in adulthood. One of the signature actions of estradiol is to alter the morphology of neural processes. In the hippocampus, estradiol modulates spines and cellular excitability that affect cognitive behaviors. In the hypothalamus, estradiol increases spine density in mediobasal hypothalamic nuclei that...

PURPOSE/OBJECTIVE Prompted by preliminary findings, this study was conducted to investigate the impact of zoledronic acid on the cancellous bone microstructure and its effect on the level of β-catenin in a mouse model of postmenopausal osteoporosis. METHODS AND MATERIALS 96 8-week-old specific-pathogen-free C57BL/6 mice were randomly divided into 4 groups (24 per group): a sham group, an ovar...