Objective(s): The prognosis of osteoporosis is very poor, and it is very important to identify a biomarker for prevention of osteoporosis. In this study, we aimed to identify candidate markers in osteoporosis and to investigate the role of candidate markers in osteogenic differentiation. Materials and Methods: Using Weighted Gene Co-Expression Network analysis, we identified three hub genes mig...

Background & Objective: Basal cell carcinoma (BCC) is a common skin cancer arising from the basal layer of the epidermis and its appendages. They are locally invasive, aggressive, and destructive of skin and the surrounding structures. β-Catenin is a multifunctional protein located to the intracellular side of the cytoplasmic membrane coded by the CTNNB1 gene, which maps to chr...

Abstract β-catenin-signaling promotes proliferation and survival in epithelial, neuronal, mesenchymal lineages, but is dispensable for B- T-cell development. β-catenin activation a common oncogenic driver throughout all types of cancer with the exception T-lymphoid malignancies. Unlike epithelial tissues, we found that T-cells consistently lack expression. Instead, both were highly sensitive to...

Many studies indicate the involvement of WNT signaling in oncogenesis and melanoma drug resistance. Receptor-interacting protein kinase (RIPK4), which targets multiple pathways such as Wnt/β-catenin, NFKB MAPK, is might be a alternative target. This supported by fact that RIPK4 levels are elevated cells compared to normal melanocytes. Since role this regulation pathway remain unknown, we tested...

目的： 检测结直肠腺癌组织及癌旁正常组织bcl-2、 β-catenin蛋白表达，探讨bcl-2、 β-catenin与患者的年 龄、性别、肿瘤部位、分化程度、与、浸润深度、淋巴结转移及TNM分期等临床病理参数的关系。 方法： 原发性结直 肠腺癌及对应的癌旁正常组织各62例用免疫组织化学方法检测bcl-2、 β-catenin蛋白表达情况。结果 结直肠癌组织bcl- 2、 β-catenin蛋白表达高于远切端正常黏膜， bcl-2与浸润深度、淋巴结转移及TNM分期有关（ P < 0.05）； β-catenin与 肿瘤的分化程度、淋巴结转移及TNM分期有关（ 0.05）。 结论： 结直肠腺癌组织bcl-2和β-catenin在结直肠癌组织 中高表达，且存在一定的相关性。

Wingless-integrated/β-catenin (Wnt/β-catenin) signaling pathway is an evolutionarily conserved which not only important for regulation of embryogenesis and organ development, but also injury repair, homeostasis tissue remodeling. Dysregulation this either by upregulation or even downregulation highly implicated in various diseases such as; liver diseases, kidney lung fibrosis, heart failure, va...

background: coronary artery disease (cad) is the major cause of mortality and morbidity worldwide. the aim of this study was to explore the effect of resveratrol (res) on canonical β-catenin/wnt and forkhead box o (foxo) pathways in cad patients.method: we performed this study on 10 metabolic syndrome patients with three-vessel cad and 10 sex-aged matched healthy subjects. the effects of res on...