The all-trans-β-carotene is a natural pigment used in various industrial fields (food, cosmetics, pharmaceuticals, etc) and possesses the higher provitamin A activity, in respect to other carotenoids. All-trans-β-carotene is produced industrially by chemical and biotechnological means. For β-carotene biotechnological production in industrial scale mated cultures of Blakeslea trispora, a heterot...

Carotenoids are effective antioxidants, which can quench singlet oxygen, suppress lipid peroxidation, and prevent oxidative damage. Both Pseudorabies virus (PRV) and human Herpes simplex virus (HSV) are DNA viruses, and their pathogenesis and immunobiology are similar. However, PRV does not infect humans. Therefore, PRV was used to infect murine macrophages (RAW264.7 cells), to mimic HSV-induce...

dunaliella salina was isolated from maharlu salt lake in shiraz, iran, and was analyzed forthe effects of salinity stress on its growth, pigment content and ascorbate peroxidase activity. growth,expressed as number of cells ml-1, which was most rapid at 2 m nacl, was reduced at salinity extremes.during the exponential phase of growth, increasing salinity from 0.5 to 4 m nacl increased chl a fro...

Mammalian genomes encode two provitamin A-converting enzymes as follows: the β-carotene-15,15'-oxygenase (BCO1) and the β-carotene-9',10'-oxygenase (BCO2). Symmetric cleavage by BCO1 yields retinoids (β-15'-apocarotenoids, C20), whereas eccentric cleavage by BCO2 produces long-chain (>C20) apocarotenoids. Here, we used genetic and biochemical approaches to clarify the contribution of these enzy...

BACKGROUND Carotenoids are natural pigments with antioxidant properties that have important functions in human physiology and must be supplied through the diet. They also have important industrial applications as food colourants, animal feed additives and nutraceuticals. Some of them, such as β-carotene, are produced on an industrial scale with the use of microorganisms, including fungi. The mu...

Mortality of neonates continues to be a major problem in humans and animals. IgA provides protection against microbial antigens at mucosal surfaces. Although β-carotene supplementation has been expected to enhance retinoic acid-mediated immune response in neonates, the exact mechanism by which β-carotene enhances IgA production is still unclear. We investigated the effect of supplemental β-caro...

Muscle atrophy increases the production of reactive oxygen species and the expression of atrophy-related genes, which are involved in the ubiquitin-proteasome system. In the present study, we investigated the effects of β-carotene on oxidative stress (100 μM-H2O2)-induced muscle atrophy in murine C2C12 myotubes. β-Carotene (10 μM) restored the H2O2-induced decreased levels of myosin heavy chain...

Article history: Received on: 21/05/2016 Revised on: 23/06/2016 Accepted on: 14/07/2016 Available online: 30/08/2016 In the present study, the effects of hypo-osmotic and hyper-osmotic shock on β-carotene and glycerol production by a native strain of Dunaliella salina isolated from Maharlu Salt Lake, Fars province, Iran, were investigated. The amount of β-carotene and glycerol at 1 h, 2 h, 8 h ...

The halotolerant microalga Dunaliella salina has been widely studied for natural 10 β-carotene production. This work shows biochemical characterization of three newly isolated 11 Dunaliella salina strains DF15, DF17 and DF40 compared with D. salina CCAP 19/30 (confirmed to 12 be D. tertiolecta) and D. salina UTEX 2538 (also known as D. bardawil). Although all three new strains 13 have been gene...