www.thelancet.com Published online May 28, 2015 http://dx.doi.org/10.1016/S0140-6736(15)60036-8 1 α1 antitrypsin is a serine antiprotease secreted by the liver. Its main function is inhibition of neutrophil elastase, a non-specifi c protease released by activated or dying neutrophils. In individuals with healthy concentrations of α1 antitrypsin, the fragile alveolar structures of the lung paren...

Ca2+ channels are voltage-gated ion present in the membrane of most excitable cells. The nomenclature for Ca2+channels was proposed by [127] and approved NC-IUPHAR Subcommittee on [70]. Most form hetero-oligomeric complexes. α1 subunit is pore-forming provides binding site(s) practically all agonists antagonists. 10 cloned α1-subunits can be grouped into three families: (1) high-voltage activat...

and Applied Analysis 3 2. Main Result Our main theorem is given by the following. Theorem 2.1. Let λ0 > 0, 0 < a ≤ 1 max{α1, α2} , |b 1| ≤ 2 α1 α2 , 0 ≤ a − b − 1 ≤ 1 max{α1, α2} . 2.1 If p ∈ P satisfies −2 2 < arg ( λ0 ( p z )a zp′ z ( p z )b ) < γ1π 2 z ∈ U , 2.2 where γj γj a, b, α1, α2 aαj 2 π tan−1 ( α1 α2 /2 cos ( βπ/2 ) cos ( a − b − 1 αjπ/2 ) 2λ0δj a, b, α1, α2 α1 α2 /2 cos ( βπ/2 ) sin...

BACKGROUND & OBJECTIVES Observation of an increased frequency of an intermediate deficiency of serum alpha1-antitrypsin (α1-AT) in patients with Tropical Pulmonary Eosinophilia (TPE) was earlier reported. Though the possibility of existence of an acquired deficiency was suggested, without phenotyping a hereditary α1-AT deficiency in TPE could not totally be ruled out. In this study, we have don...

BACKGROUND Alpha1 anti-trypsin (α1-AT), a serine protease inhibitor synthesized in the liver, is a major circulating antiprotease that provides defense against proteolytic damage in several tissues. Its deficiency is associated with airflow obstruction. The present study aimed to explore the role of α1-AT as a biomarker of airflow performance in chronic liver disease (CLD). MATERIAL/METHODS S...

α1-Adrenergic receptors (α1-ARs), as one of the most important members of G protein-coupled receptors (GPCRs), can mediate lots of physiological responses of the sympathetic nervous system. Until now, α1-ARs have been divided into at least three subtypes, α1A, α1B, and α1D, which distribute in various tissues and organs. In this research, we designed and synthesized several napthalimide-based s...

We describe the expression of the extracellular domain of the human α1 nicotinic acetylcholine receptor (nAChR) in lepidopteran insect cells (i-α1-ECD) and its suitability for use in antigen-specific therapies for Myasthenia Gravis (MG). Compared to the previously expressed protein in P. pastoris (y-α1-ECD), i-α1-ECD had a 2-fold increased expression yield, bound anti-nAChR monoclonal antibodie...

BACKGROUND We have shown that the ouabain-sensitive α2 Na,K-ATPase is required for adrenocorticotropic hormone (ACTH)-induced hypertension and gestational blood pressure regulation. It is therefore of interest to explore whether this binding site participates in the development of other forms of hypertension, such as deoxycorticosterone acetate (DOCA)-salt using mutant mice with altered sensiti...

α1-Adrenergic receptors (α1-ARs) are important players in peripheral and central nervous system (CNS) regulation and function and in mediating various behavioral responses. The α1-AR family consists of three subtypes, α1A, α1B and α1D, which differ in their subcellular distribution, efficacy in evoking intracellular signals and transcriptional profiles. All three α1-AR subtypes are present at r...

INTRODUCTION Chronic obstructive pulmonary disease (COPD) has been recently defined as a systemic pulmonary inflammatory disease, and congenital α1 antitrypsin deficiency is one of the well-established genetic risk factors for chronic obstructive pulmonary disease. The aim of our study was to evaluate the possible associations of α1 antitrypsin with inflammatory markers - CRP, sCD14, TNF-α, sTN...