α-Aminophosphonates (4a-h) were synthesized in one-pot simultaneous reaction of aniline(1), dimethylphosphite(3), and different aromatic aldehydes (2) by Kabachnik–Fields reaction in ethanol at room temperature. The products (4a-h) were obtained in good yields. All these compounds were found to exhibit moderate to good antimicrobial activity.

Porous graphene oxide can be used as a metal-free catalyst in the presence of air for oxidative coupling of primary amines. Herein, we explore a GO-catalyzed carbon-carbon or/and carbon-heteroatom bond formation strategy to functionalize primary amines in tandem to produce a series of valuable products, i.e., α-aminophosphonates, α-aminonitriles, and polycyclic heterocompounds. Furthermore, whe...

The hemolytic activity of some newly synthesized aminomethanephosphonic acid derivatives was studied. The compounds studied differed in their polarity and the hydrophobicity of the electronic substituents at their nitrogen and carbon atoms. It was found that acyclic aminophosphonates exhibited significantly stronger hemolytic properties than cyclic aminophosphonates. To cause the same level of ...

Comparative assessment of in vitro and in vivo biological activity of anthracene-derived aminophosphonates, bis-aminophosphonates and poly(aminophosphonate)s, namely poly(oxyethylene aminophosphonate)s (4,5) and poly[oxyethylene aminophosphonate-co-H-phosphonate)]s, (6,7), were carried out in order to establish their value as potential drug candidates. The compounds were tested for in vitro cyt...

LiTMP metalated dimethyl N-Boc-phosphoramidates derived from 1-phenylethylamine and 1,2,3,4-tetrahydronaphthalen-1-ylamine highly selectively at the CH3O group to generate short-lived oxymethyllithiums. These isomerized to diastereomeric hydroxymethylphosphonamidates (phosphate–phosphonate rearrangement). However, s-BuLi converted the dimethyl N-Boc-phosphoramidate derived from 1-phenylethylami...

Hemolysis and fluidization of erythrocytes (RBC) membranes by some newly synthesized aminophosphonates as well as their potency to induce electrolyte efflux from cucumber (Cucumis sativus cv "Wisconsin") cotyledons were studied. Also, the chlorophyll content in aminophosphonate-treated cotyledons was affected. The compounds studied differed mainly in hydrophobicity of their substituents at the ...