Background/Aim—Interleukin (IL) 12 is involved in the mucosal response during intestinal inflammation but its role is not fully understood. The response of human lamina propria T lymphocytes (T-LPL) to IL-12 in terms of interferon ã (IFN-ã) release and proliferation was investigated, exploring whether IL-15 and IL-7 cooperate with IL-12. The role of accessory molecules (CD2 and CD28) was also i...

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Resonantly-enhanced one-color two-photon ~111! ionization spectra of jet-cooled methylamines (CH3NH2 and CH3ND2) reveal the vibrational structures of these molecules in predissociative à states. Rotational fine structure is clearly resolved for CH3ND2 at the origin and first wagging vibrational level in the excited state. The spectral linewidth becomes homogeneously broadened to give only vibra...

Background—Inflammatory bowel disease (IBD) is characterised by chronic intestinal inflammation and increased epithelial permeability. Both tumour necrosis factor á (TNF-á) and interferon ã (IFN-ã) have been implicated in IBD. Aims—To understand better the eVects of these cytokines on epithelial cell function. Methods—T84 cells were cultured with IFN-ã and TNF-á and changes in transepithelial r...

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Background—Impairment of intestinal barrier function occurs under a variety of inflammatory conditions and is mediated at least in part by interferon ã (IFN-ã) induced nitric oxide (NO) production. Previous in vivo studies have shown that systemic lipopolysaccharide treatment caused an induction of the rat inducible nitric oxide synthase (iNOS) mRNA primarily in villus cells, rather than in und...

Extensive ab initio calculations were performed for the X̃ 2E′ and à 2E′′ states of Ag3, using a newly constructed basis set for Ag. An important goal of these calculations is to guide the analysis of the experimentally observed à 2E′′-X̃ 2E′ electronic spectrum. Vibrational frequencies of Ag3 for both the X̃ and à state are reported. Spectroscopically obtainable parameters describing the Jahn-Tel...

Aims—Previous studies have implied that interferon gamma (IFN-ã) is involved in the pathogenesis of endotoxin induced uveitis (EIU) in the rat. This study investigated the source of IFN-ã in the iris during EIU. Methods—Whole mounts of iris were isolated from Lewis rats before and at different times (from 4 hours to 14 days) after foot pad injection of 200 μg Salmonella typhimurium lipopolysacc...

There are two errors in the RP-1164 row and Nucleotide Change and Protein Change columns of Table 1. The mutation c.863dupA should be c.862dupA and the mutation p.M289Y à 18 should be p.T288Nfs à 19. There is also an error in Fig 1 under the panel RP-1164. The mutation p.M289Y à 18 should be p.T288Nfs à 19. Please view the correct Table 1 and Fig 1 here. access article distributed under the ter...