The present study investigated whether invertebrate body burdens can be used to predict metal-induced effects on aquatic invertebrate communities. Total dissolved metal levels and four invertebrate taxa (Leuctra sp., Simuliidae, Rhithrogena sp. and Perlodidae) were sampled in 36 headwater streams located in the north-west part of England. Using the River Invertebrate Prediction and Classificati...

Vesicular zinc (Zn(2+)) is found in a subset of glutamatergic nerve terminals throughout the mammalian forebrain and is colocalized with glutamate. Despite well-documented neuromodulatory roles, exocytosis of endogenous Zn(2+) from presynaptic terminals has never been directly demonstrated, because existing studies have measured elevated Zn(2+) concentrations by examining the perfusate. Thus, t...

Biofortification of crops that provide major food staples to large, poor rural populations offers an appealing strategy for diminishing public health problems attributable to micronutrient deficiencies. The objective of this first-stage human study was to determine the increase in quantity of zinc (Zn) absorbed achieved by biofortifying wheat with Zn. Secondary objectives included evaluating th...

An experiment was conducted to determine the effect of high dietary intakes of Zn and Cu and their combination on growth performance of weanling pigs with diverse health status and management strategies. Twelve experiment stations cooperated and used a total of 1,356 pigs that averaged 6.55 kg BW and 22.2 d age at weaning. The four dietary treatments, all of which met or exceeded NRC requiremen...

We conducted two trials (n = 144 and 96) to evaluate the response of feeding either ZnSO4 x H2O or a zinc-lysine complex (ZnLys) in combination with various lysine levels on growth performance, liver, kidney, and 10th rib Zn concentration, serum Zn humoral immune response and absorption of Zn (chromic oxide method) of young pigs. The following treatments were started after a 7-d postweaning adj...

Zn deficiency is among the leading health risk factors in developing countries. Breeding of Zn-enriched crops is expected to be facilitated by molecular dissection of plant Zn hyperaccumulation (i.e., the ability of certain plants to accumulate Zn to levels >100-fold higher than normal plants). The model hyperaccumulators Arabidopsis halleri and Noccaea caerulescens share elevated nicotianamine...

I. Rats were made severely iron-deficient by feeding with Fe-deficient diets, which contained adequate amounts of zinc. 2. Ten days after an oral dose of 250 ,ug %n the Fe-deficient rats had retained 17 yo whereas control rats had retained only 8 yo of the dose. 3. When unlabelled Zn was given intravenously to the Fe-deficient and control rats there was a reduction in retention of the orally ad...

The lactating mammary gland is composed of multiple cell types that tightly coordinate the accumulation, production, and secretion of milk components, including essential metals such as zinc (Zn). Our previous studies in animal and cell models implicated the Zn transporter Zip3 (Slc39a3) in mammary gland Zn acquisition. Herein, we investigated this hypothesis directly by utilizing Zip3-null mic...

Zinc (Zn) has significant anti-oxidant and anti-inflammatory activity. Zn deficiency can occur in subsets of patients with cystic fibrosis (CF) especially those with malabsorption and impaired growth. Although supplemental Zn has significantly reduced infections in various disorders, its efficacy has not been thoroughly investigated in CF. We performed a double blind placebo controlled pilot st...

In the last 35 years, zinc (Zn) has been examined for its potential role in the disease multiple sclerosis (MS). This review gives an overview of the possible role of Zn in the pathogenesis of MS as well as a meta-analysis of studies having measured Zn in serum or plasma in patients with MS. Searching the databases PubMed and EMBASE as well as going through reference lists in included articles ...