Photodynamic antimicrobial chemotherapy is an attractive and novel therapeutic approach to treat microbial infections. Antimicrobial peptides (AMPs) have the potential specifically target kill microorganism while showing no effect toward mammalian cells. In current study, peptide (GGG(RW)3), analogue of MP-196, was conjugated a zinc phthalocyanine (ZnPc) photosensitizer (PS) for photoinactivati...

A major challenge in photodynamic therapy (PDT) is the development of new tumor-targeting photosensitizers. The tumor-specific activation is considered to be an effective strategy for designing these photosensitizers. Herein, we describe a novel tumor-pH-responsive supramolecular photosensitizer, LDH-ZnPcS8, which is not photoactive under neutral conditions but is precisely and efficiently acti...

Mitochondria play a key role in the regulation of apoptosis induced by numerous antitumor chemotherapeutic and other toxic agents. Photodynamic therapy (PDT) exerts significant cellular killing efficacy through either an apoptotic or necrotic cell death pathway. This study investigated the mechanism underlying the killing effects of a novel amphipathic photosensitizer [di-sulfonated di-phthalim...

Photodynamic therapy (PDT) is a cancer treatment modality based on the administration of a photosensitizer (PS), which accumulates preferentially in tumor cells. Subsequent irradiation of the neoplastic area triggers a cascade of photochemical reactions that leads to the formation of highly reactive oxygen species responsible for cell inactivation. Photodynamic treatments in vitro are performed...

The supramolecular coordination of zinc (II) phthalocyanine (Zn-Pc) with V-shaped bi-pyridine in a nano-reactor is probed by scanning tunneling microscopy (STM) at liquid/solid interface. Combined with density functional theory (DFT) calculations, our STM results show that the V-shaped bi-pyridine and Zn-Pc can generate stable "odd-even" patterned architectures in the TCDB network through a two...

Recently the importance of measuring in vivo action spectra for photodynamic therapy (PDT) with various photosensitizers was pointed out in this journal [1]. It was shown that the effect of PDT with zinc phthalocyanine tetrasulphonic acid (ZnPcS4) increases considerably when the wavelength of the activating light is increased from 680 to 692 nm. In this regard a further comparison with haematop...

Water solubility of phthalocyanines (Pcs) usually increases by the introduction of charged or carboxy substituents in the peripheral positions of the macrocycle. As a result, such structural changes influence their photophysical and photochemical properties as photosensitizers. Phthalocyanines substituted with four or eight terminal carboxyl groups and having in some cases additional eight posi...