نتایج جستجو برای: zinc metalloenzymes

تعداد نتایج: 74030  

2013

Copper (II) is a biologically active essential ion and it forms the active centers in several metalloenzymes and proteins. Its chelating ability and positive redox potential allow participation in biological transport reactions. The copper atom transforms between the Cu(I) and Cu(II) oxidation states in redox reactions involving copper containing enzymes. This is an essential factor for many of...

Journal: :Journal of Computational Chemistry 2001
Per E. M. Siegbahn

Different models to treat metal-catalyzed enzyme reactions are investigated. The test case chosen is the recently suggested full catalytic cycle of manganese catalase including eight different steps. This cycle contains O—O and O—H activations, as well as electron transfer steps and redox active reactions, and is therefore believed to be representative of many similar systems. Questions concern...

Journal: :Bioorganic & medicinal chemistry 2014
Megan V Doble Andrew C C Ward Peter J Deuss Amanda G Jarvis Paul C J Kamer

Oxidation reactions are an important part of the synthetic organic chemist's toolkit and continued advancements have, in many cases, resulted in high yields and selectivities. This review aims to give an overview of the current state-of-the-art in oxygenation reactions using both chemical and enzymatic processes, the design principles applied to date and a possible future in the direction of hy...

Journal: :Journal of Magnetic Resonance (1969) 1978

Journal: :Journal of the American Chemical Society 2005
Takafumi Ueno Tomomi Koshiyama Masataka Ohashi Kazuyoshi Kondo Masaharu Kono Atsuo Suzuki Takashi Yamane Yoshihito Watanabe

New methods for the synthesis of artificial metalloenzymes are important for the construction of novel biocatalysts and biomaterials. Recently, we reported new methodology for the synthesis of artificial metalloenzymes by reconstituting apo-myoglobin with metal complexes (Ohashi, M. et al., Angew Chem., Int. Ed. 2003, 42, 1005-1008). However, it has been difficult to improve their reactivity, s...

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